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Books > Science & Mathematics > Science: general issues > History of science
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The Life of a Virus - Tobacco Mosaic Virus as an Experimental Model, 1930-1965 (Paperback, 2nd ed.)
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The Life of a Virus - Tobacco Mosaic Virus as an Experimental Model, 1930-1965 (Paperback, 2nd ed.)
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We normally think of viruses in terms of the devastating diseases
they cause, from smallpox to AIDS. But in "The Life of a Virus, "
Angela N. H. Creager introduces us to a plant virus that has taught
us much of what we know about all viruses, including the lethal
ones, and that also played a crucial role in the development of
molecular biology.
Focusing on the tobacco mosaic virus (TMV) research conducted in
Nobel laureate Wendell Stanley's lab, Creager argues that TMV
served as a model system for virology and molecular biology, much
as the fruit fly and laboratory mouse have for genetics and cancer
research. She examines how the experimental techniques and
instruments Stanley and his colleagues developed for studying TMV
were generalized not just to other labs working on TMV, but also to
research on other diseases such as poliomyelitis and influenza and
to studies of genes and cell organelles. The great success of
research on TMV also helped justify increased spending on
biomedical research in the postwar years (partly through the
National Foundation for Infantile Paralysis's March of Dimes)--a
funding priority that has continued to this day.
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