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Drugs Affecting Lipid Metabolism - Risks Factors and Future Directions (Paperback, Softcover reprint of the original 1st ed. 1996)
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Drugs Affecting Lipid Metabolism - Risks Factors and Future Directions (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Medical Science Symposia Series, 10
Expected to ship within 10 - 15 working days
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Even a brief scan of the table of contents of the present volume is
enough to disclose the diversity of research interests and opinions
in the field of lipidology. It is precisely this diversity that is
the strength of our field and that was showcased by the XII
International Symposium of DRUGS AFFECTING LIPID METABOLISM (DALM).
The papers published here from these proceedings may be divided
into three categories: those that define-and refine---our
understanding ofthe clinical benefit of aggressive lipid
management, those that develop our knowledge of ris!. assessment,
and those that discuss the genetic, bio~hemical, and biophysical
mechanisms underlying the pathology of coronary heart disease. On
the clinical front, further analysis of the results of the
Scandinavian Simvastatin Survival Study (4S) has indicated the
cost-effectiveness of therapy in patients with established coronary
heart disease. The West of Scotland Coronary Prevention Study
(WOSCOPS), whose methodology was described at the DALM XII
symposium, has demonstrated in a mostly primary-prevention
population what 4S demonstrated for secondary prevention the year
before: aggressive lipid-regulating therapy reduces coronary heart
disease morbidity and mortality rates without concurrently
increasing mortality from noncardiovascular causes. In the future,
important considerations will be to develop protocols that maximize
benefit in groups underrepresented in traditional clinical research
for example, women and the elderly-and to improve compliance to
existing treatment regimens. Furthermore, antioxidant, omega-3
fatty acid, and gene therapies warrant further investigation.
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