The biological interactions of living organisms, and
protein-protein interactions in particular, are astonishingly
diverse and present numerous challenges to modern biomolecular
research because of their complexity. Analysis of patterns and
principles governing these interactions has prompted a rapid
development of computational methods to identify protein
interaction partners and to understand the roles of individual
components of protein interaction networks in cell functions.
This book integrates different approaches from bioinformatics,
biochemistry, computational analysis and systems biology to offer
the reader a comprehensive global view of the diverse data on
protein-protein interactions and protein interaction networks. It
brings together the descriptions of experimental techniques and
expounds on different computational algorithms for protein network
analysis and prediction of protein and domain interactions, with
each chapter containing a description of the problem, a review of
methods and algorithms, a list of resources and current
conclusions.
Features
a [ Reviews experimental techniques for identification of
protein interactions
a [ Discusses protein interaction databases and methods of
integrating data from diverse sources
a [ Describes computational methods to predict protein and
domain interaction partners
a [ Explores the properties of interaction interfaces and
highlights approaches to model the assembly of protein
complexes
a [ Examines the topological and dynamical properties of protein
interaction networks and presents the tools for comparative
analysis of these networks
Written by leading experts, Protein-protein Interactions and
Networksprovides a broad, thorough and multidisciplinary coverage
of this field. It will be invaluable to researchers from academia
and the bioinformatics industry, as well as an excellent auxiliary
text for graduate students studying the topic.
General
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