Molecular recognition, also known as biorecognition, is the
heart of all biological interactions. Originating from protein
stretching experiments, dynamic force spectroscopy (DFS) allows for
the extraction of detailed information on the unbinding process of
biomolecular complexes. It is becoming progressively more important
in biochemical studies and is finding wider applications in areas
such as biophysics and polymer science. In six chapters, Dynamic
Force Spectroscopy and Biomolecular Recognition covers the most
recent ideas and advances in the field of DFS applied to
biorecognition:
- Chapter 1: Reviews the basic and novel aspects of
biorecognition and discusses the emerging capabilities of
single-molecule techniques to disclose kinetic properties and
molecular mechanisms usually hidden in bulk measurements
- Chapter 2: Describes the basic principle of atomic force
microsocopy (AFM) and DFS, with particular attention to
instrumental and theoretical aspects more strictly related to the
study of biomolecules
- Chapter 3: Overviews the theoretical background in which
experimental data taken in nonequilibrum measurements of
biomolecular unbinding forces are extrapolated to equilibrium
conditions
- Chapter 4: Reviews the most common and efficient strategies
adopted in DFS experiments to immobilize the interacting
biomolecules to the AFM tip and to the substrate
- Chapter 5: Presents and discusses the most representative
aspects related to the analysis of DFS data and the challenges of
integrating well-defined criteria to calibrate data in automatic
routinary procedures
- Chapter 6 Overviews the most relevant DFS applications to study
biorecognition processes, including the biotin/avidin pair, and
selected results on various biological complexes, including
antigen/antibody, proteins/DNA, and complexes involved in adhesion
processes
- Chapter 7 Summarizes the main results obtained by DFS applied
to study biorecognition processes with forthcoming theoretical and
experimental advances
Although DFS is a widespread, worldwide technique, no books
focused on this subject have been available until now. Dynamic
Force Spectroscopy and Biomolecular Recognition provides the state
of the art of experimental data analysis and theoretical
procedures, making it a useful tool for researchers applying DFS to
study biorecognition processes.
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