Glycoprotein Methods and Protocols - The Mucins (Hardcover, 2000 ed.)

The mucins (mucus glycoproteins) have long been a complex corner of glycoprotein biology. While dramatic advances in the separation, structural an- ysis, biosynthesis, and degradation have marked the progress in general glycop- tein understanding, the mucins have lagged behind. The reasons for this lack of progress have always been clear and are only now being resolved. The mucins are very large molecules; they are difficult to separate from other molecules present in mucosal secretions or membranes; they are often degraded owing to natural protective functions or to isolation methodology and their peptide and oligos- charide structures are varied and complex. Understanding these molecules has demanded progress in several major areas. Isolation techniques that protect the intact mucins and allow dissociation from other adsorbed but discrete molecules needed to be developed and accepted by all researchers in the field. Improved methods for the study of very large molecules with regard to their aggregation and polymerization were also needed. Structural analysis of the peptide domains and the multitude of oligosaccharide chains was required for smaller sample sizes, for multiple samples, and in shorter time. In view of these problems it is perhaps not surprising that the mucins have remained a dilemma, of obvious biological importance and interest, but very difficult to analyze.

General

Imprint:	HumanaPress
Country of origin:	United States
Series:	Methods in Molecular Biology, 125
Release date:	March 2000
First published:	2000
Editors:	Anthony P. Corfield
Dimensions:	235 x 155 x 28mm (L x W x T)
Format:	Hardcover
Pages:	506
Edition:	2000 ed.
ISBN-13:	978-0-89603-720-5
Categories:	Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
LSN:	0-89603-720-7
Barcode:	9780896037205

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