"Molecular Diagnostics andTreatment of Pancreatic Cancer
"describes the different emerging applications of systems biology
and howit is shaping modern pancreatic cancer research. This book
begins by introducing the current state of the art knowledge,
trends in diagnostics, progress in disease model systems as well as
new treatment and palliative care strategies in pancreatic cancer.
Specific sections are dedicated to enlighten the readers to newer
discoveries that have emerged from gene expression profiling,
proteomics, metabolomics and systems level analyses of pancreatic
cancer datasets. First of a kind and novel network strategies to
understand oncogenic Kras signaling in pancreatic tumors are
presented. The attempts to computationally model and prioritize
microRNAs that cause pancreatic cancer resistance are
alsohighlighted.
Addressing this important area, "Molecular Diagnostics and
Treatment of Pancreatic Cancer" provides insights into important
network evaluation methodologies related to pancreatic cancer
related microRNAs targetome. There are dedicated chapters on
critical aspects of the evolving yet controversial field of
pancreatic cancer stems cells. The work concludes by discussing the
applications of network sciences in pancreatic cancer drug
discovery and clinical trial design.
Encompasses discussion of innovative tools including expression
signatures in cell lines, 3D models, animal xenograft models,
primary models and patient derived samples, aiding subversion of
traditional biology paradigms, and enhancing comprehension across
conventional length and temporal scalesCoverage includes novel
applications in targeted drugs, polypharmacology, network
pharmacology and other related drug development arenas - helping
researchers in pancreatic cancer drug discoverySummarizes many
relevant computational and clinical references from fast-evolving
literatureComprehensive glossary helps newer readers understand
technical terms and specialized nomenclature"
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