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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Lipids
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Direct Mechanisms in Cholesterol Modulation of Protein Function (Hardcover, 1st ed. 2019)
Loot Price: R2,789
Discovery Miles 27 890
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Direct Mechanisms in Cholesterol Modulation of Protein Function (Hardcover, 1st ed. 2019)
Series: Advances in Experimental Medicine and Biology, 1135
Expected to ship within 10 - 15 working days
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In this book, renowned scientists describe how cholesterol
interacts with various proteins. Recent progress made in the
high-resolution visualization of cholesterol-protein interactions
using crystallography and cryogenic electron microscopy has
substantially advanced the knowledge of critical features. These
features enable specific recognition of the cholesterol molecule by
proteins, a process that was built on earlier studies using binding
assays, computational modeling and site-directed mutagenesis.
Direct Mechanisms in Cholesterol Modulation of Protein Function
offers comprehensive insights into the current understanding of
cholesterol-driven modulation of protein function via direct
sensing. Its nine chapters are organized into two distinct parts.
In the first part, the chapters introduce the reader to the general
characteristics of cholesterol binding sites in proteins. This part
starts with a tour into common cholesterol recognition motifs,
followed by an overview of the major classes of steroid-binding
proteins. It then continues with two chapters that present a
comprehensive analysis of molecular and structural characteristics
of cholesterol binding sites in transmembrane and soluble protein
domains. In the second part of the book, examples of cholesterol
binding sites and consequences of specific cholesterol recognition
for protein function are presented for G protein-coupled receptors,
ion channels and cholesterol-transporting proteins. The book is
valuable for undergraduate and graduate students in biochemistry
and nutrition, as well as basic science and medical researchers
with a keen interest in the biophysical properties of cholesterol
and physiological consequences of cholesterol presence in
biological systems.
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