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Proton Pump Inhibitors (PPIs) - Prevalence of Use, Effectiveness & Implications for Clinicians (Hardcover)
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Proton Pump Inhibitors (PPIs) - Prevalence of Use, Effectiveness & Implications for Clinicians (Hardcover)
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Proton pump inhibitors (PPIs) have become a mainstay of therapy not
only in the practice of gastroenterology, but also for general
medicine and even for the general public. Recently, proton pump
inhibitors have been associated with a number of potential
complications including impaired vitamin and mineral absorption,
altered drug metabolism and increased risk for infections. The
outline for the basis for these reported risks are examined in this
book, the current clinical evidence is discussed, and the authors
offer insight into the likely clinical significance of each
complication. Furthermore, the pathophysiology of acid secretion
and inhibition, with a specific focus on the pharmacological
principles surrounding the use of PPIs are reviewed. Relevant
information on the management of acid-related disordered is
provided for clinicians. Other chapters explore the current
literature on potential complications associated with long-term PPI
use, the benefits and risks of routine use of proton pump
inhibitors in the intensive care unit (ICU), often associated with
adverse events such as a significantly increased risk of infectious
complications, and the use and misuse of proton pump inhibitors in
the general population.
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