Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of
cellular functions. Aryl nitrite and glyceryl trinitrate,
representative intravasadilators, were introduced as therapeutic
agents more than a century ago for relief from acute attacks of
angina. The vasodilator action is mediated by the release of NO
following treatment. NO has important therapeutic applications in
several diseases such as inflammatory diseases, erectile
dysfunction, inflammation, pain and neural protective activity.
However, the role of NO in cancer and its application in therapy
has received little attention. This monograph will be the first to
focus on studies that investigate the role of NO in tumor cell
pathogenesis, growth, angiogenesis, response to cytotoxic therapies
and NO translational applications in cancer therapy, alone or in
conjunction with other therapies.
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