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Biology of the Arterial Wall (Hardcover, 1999 ed.)
Loot Price: R4,607
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Biology of the Arterial Wall (Hardcover, 1999 ed.)
Series: Basic Science for the Cardiologist, 1
Expected to ship within 12 - 17 working days
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Biology of the Arterial Wall is intended as a general reference
text concerned with the biology of the vascular cells and the blood
vessel wall under physiological and pathological conditions. One of
the major functions of the arteries is to maintain a continuous
blood flow to the organs whatever the pressure conditions, thanks
to the vasomotor tone of the smooth muscle cells. Great advances
have been made over the last decade in the understanding of the
endothelial cells as integrators and transducers of signals
originating from the blood stream. The pluripotent control
functions of the endothelial cells in the vessel wall are now well
recognized. A review of endothelial functions and dysfunctions is
presented. Cell biology and molecular genetic studies have now
identified an array of molecules elaborated by endothelial cells
and vascular smooth muscle cells and by the blood-borne elements
which interact with artery cells, defending the artery against
injury and modulating evolving abnormal processes. Molecules which
induce or inhibit endothelial and/or smooth muscle cells are
currently under great scrutiny. Angiogenesis, which plays a major
role in tumor growth, but may also be beneficial as a healing
process in muscle ischemia, is discussed. Apoptosis, or programmed
cell death, has only recently been recognized as an essential
process in blood vessel modeling and remodeling. An overview of
apoptosis in the vascular system is presented. It is increasingly
evident that the adjustments of the blood vessel wall are made in
the presence of deforming disease processes such as hypertension
and atherosclerosis. The second part of the book is concerned with
the blood vessel wall in disease conditions. Several chapters
review the role of the vessel and vascular cells in inflammation,
and vascular remodeling during arterial hypertension and aging. One
chapter is devoted to atherogenesis, atheroma and plaque
instability, followed by the pathophysiology of post-angioplasty
restenosis, which is a crucial issue in modern interventional
cardiology.
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