Although knowledge of the development and differentiation of glial
cells has significantly increased in recent years, there are still
many questions unanswered. The first section of the book is devoted
to this very active topic and includes contributions on Schwann
cells, oligodendrocytes, astroglia and microglia.
The second section of the book covers cellular interactions, the
role they play on myelination and remyelination, how these
interactions take place and the molecules involved.
The third section of this volume focuses on the interactions of
neurons with glial cells and their role in brain function.
Neuron-glia cross talk appears to be fundamental for synaptic
transmission and several chapters in this section address this
topic.
The topic of how glial cells react to brain injury and how they
participate in neuroprotection and brain repair is covered in
section four of this book. As our knowledge about the molecules
involved in the regenerative properties of glia increases, new
avenues are open for the use of genetically modified glia with
therapeutic purposes.
The final section of the book is devoted to therapeutic approaches
to tumours, viral and prion infections. Gene therapy is a promising
approach for the treatment of gliomas, one of the most devastating
forms of cancer. A chapter on prion diseases and microglia
addresses a question of tremendous actuality, since prion diseases
in cows is at this moment the major veterinary problem in Europe
and has created a considerable social alarm.
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