The past 6 years since the first edition of this book have seen
great progress in the development of genetically engineered mouse
(GEM) models of cancer. These models are finding an important role
in furthering our understanding of the biology of malignant
disease. A comfortable position for GEM models in the routine
conduct of screening for potential new therapeutics is coming more
slowly but is coming. Increasing numbers of genetically engineered
mice are available, some with conditional activation of oncogenes,
some with multiple genetic changes providing mouse models that are
moving closer to the human disease.
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