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Cellular Adhesion - Molecular Definition to Therapeutic Potential (Paperback, Softcover reprint of the original 1st ed. 1994)
Loot Price: R2,868
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Cellular Adhesion - Molecular Definition to Therapeutic Potential (Paperback, Softcover reprint of the original 1st ed. 1994)
Series: New Horizons in Therapeutics
Expected to ship within 10 - 15 working days
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This volume focuses on recent developments in our understanding of
selected adhesion processes that may offer new approaches to
developing therapeutics for a variety ofdiseases. The volume first
introduces the molecules involved in key adhesive processes, then
describes the biological consequences of several adhe- sive
interactions, and closes with a description of the initial
therapeutic ap- proaches to antagonizing. adhesion. These papers
were originally presented at the SmithKline Beecham Pharmaceuticals
Seventh U. S. Research Symposium held in Philadelphia in October of
1992. ofacell to asurface. In its simplestsense, cellularadhesion
is the adherence The cells of interest in the context of this
volume are bacterial and mammalian, with an emphasis on leukocytes;
surfaces can be other cells and tissues (such as bone), matrix
proteins, or inanimate objects such as in-dwelling medical devices
and catheters. Interaction between adhesion molecules usually
results in a spe- cific biological response. Adhesion is a form
ofcellularcommunication, and represents the way a cell senses its
environment through contact. Like hormones and cytokines, the sol-
uble mediators used by cells for communication, adhesion molecules
are defined molecular entities that recognize specific receptor
structures on the surface to which they adhere. Recent activity has
focused on defining the structure of the individual molecules
responsible for many types ofcellularadhesion. New adhe- sion
proteins are being cloned with the help of specific antibodies and
precise functional assays.
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