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Books > Science & Mathematics > Physics > Applied physics & special topics > Biophysics
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Ion Channel Reconstitution (Paperback, 1986 ed.)
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Ion Channel Reconstitution (Paperback, 1986 ed.)
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It is now over 30 years since the idea of ion-conducting pores
burst on the elec- trophysiological scene, 15 years since these
were generalIy realized to be mem- brane-spanning proteins, and 10
years since the first observations of single ion channels from
higher organisms were made. During the past 5 years, several
integral membrane channel proteins have been purified in a
functionalIy competent state: the nicotinic acetylcholine receptor,
the Na + channel, mitochondrial "VDAC," and a variety of porins.
The stage is thus set to attack ion channels in the same ways that
biochemists have been attacking enzymes for decades: isolation
folIowed by functional analysis in as simple a system as possible,
with a view towards understanding the molecular mechanisms ofthe
protein's behavior and how this is related to the underlying
molecular structure. This is always a daunting task, alI the more
so with ion channels because of our still primitive and scanty
understanding of channel structures and because of the difficulty
in iso- lating functionally active channel proteins. In this
volume, which can be considered a biochemically slanted companion
to Sakmann and Neher's Single-Channel Recording, I have tried to
present a view of the current landscape of ion-channel
reconstitution. These chapters illustrate not only the different
approaches and techniques of the major practitioners of ion-
channel reconstitution but, as importantly, the varied motivations
for doing this kind of work.
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