Regenerative medicine is a highly interdisciplinary field, with
contributions from medicine, engineering, and chemistry. Chemical
biology plays a key role - small molecules are involved in
differentiating, reprogramming and manipulating stem cells and in
enabling transplantation.
In "Chemical Biology in Regenerative Medicine, "an international
team of experts provides an overview of progress towards clinical
application in the areas of transplantation (allogenic and
autologous), manipulation of niche environment and homing, and cell
reprogramming (trans-differentiation and de-differentiation). The
book highlights the interdisciplinary approaches undertaken to
resolve current technical problems in regenerative medicine, with
special attention paid to small molecules and biomaterials
engineering. It also includes an overview of the current regulatory
climate and discusses the future of these therapies. Topics covered
include: Wnt Signaling in Regulation of Stem CellsDirected
Cardiomyogenesis of Pluripotent Stem CellsChemical Genetics in
Cardiomyocyte Generation" "Challenges and New Directions for
Cardiac ReprogrammingComparative Analysis of Adult Stem Cell
NichesChemicals and Stem Cells for Promoting RegenerationChemically
Induced Pluripotent Stem Cells (CiPSC): A Potential Chemical
Biological Breakthrough in Reprogramming?An Introduction to
Cellular Reprogramming: The Plasticity of Cell Fates and
IdentitiesChemicals Facilitating ReprogrammingChemicals
Facilitating Reprogramming: Targeting the SAM Binding Site to
Identify Novel Methyltransferase InhibitorsBiomaterials for
Directed differentiation
"Chemical Biology in Regenerative Medicine" is an essential
overview of this emerging technology for researchers in academia,
industry and clinical settings working in regenerative medicine,
chemical biology, biochemistry, cell biology, biomaterials and
bioengineering.
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