The objective of this" CTMI" volume is to provide readers with
a foundation for understanding what ADARs are and how they act to
affect gene expression and function. It is becoming increasingly
apparent that ADARs may possess roles not only as enzymes that
deaminate adenosine to produce inosine in RNA substrates with
double-stranded character, but also as proteins independent of
their catalytic property. Because A-to-I editing may affect
base-pairing and RNA structure, processes including translation,
splicing, RNA replication, and miR and siRNA silencing may be
affected. Future studies of ADARs no doubt will provide us with
additional surprises and new insights into the modulation of
biological processes by the ADAR family of proteins. "
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