Targeting Functional Centers of the Ribosome (Hardcover, 2011 Ed.)

This thesis describes research into the mode of function, inhibition, and evolution of the ribosomal catalytic center, the Peptidyl Transferase Center (PTC)--research that has already led to attempts at improving PTC antibiotics. The PhD candidate carried out two parallel studies. One using a combination of X-ray crystallography, biochemistry, molecular biology, and theoretical studies to obtain crystal structures of ribosomal particles with antibiotics that target the PTC, revealing the modes of action, resistance, cross-resistance and discrimination between ribosomes of eubacterial pathogens and eukaryotic hosts. In the second parallel study, the candidate synthesized a ribosomal substructure--one that may represent the minimal entity capable of catalyzing peptide bond formation--shedding light on the origin of the ribosome itself. Content Level Research

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Springer Theses
Release date:	February 2011
First published:	2011
Authors:	Chen Davidovich
Dimensions:	235 x 155 x 10mm (L x W x T)
Format:	Hardcover
Pages:	74
Edition:	2011 Ed.
ISBN-13:	978-3-642-16930-4
Categories:	Books > Science & Mathematics > Chemistry > Organic chemistry > General Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
LSN:	3-642-16930-9
Barcode:	9783642169304

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