After 13 years there are new areas to discuss and more recent
trials to be included. Good clinical practice; evaluation of
quality of life; measurement of the benefit:risk comparison;
determination of cost- effectiveness and cost utility; stopping
rules for trials; meta-analysis and subgroup analysis are all new
sections. The references are expanded from 305 to 512 and include
the recent advances in trial design, such as the n-of-1 trials and
megatrials, and up-to-date examples to illustrate the points made
in the 20 chapters.
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