Calcium Regulation by Calcium-Binding Proteins in Neurodegenerative Disorders (Paperback, Softcover reprint of the original 1st ed. 1995)

Claus W. Heizmann and Katharina Braun ore than 10,000 articles were published in 1994 on calcium, M 2 emphasizing the widespread interest and progress in Ca +- 2 related research. This book focuses mainly on Ca + -binding pro- 2 teins in the central nervous system, where Ca + ions have been found to activate fundamental processes such as release of neu- rotransmitters, axonal flow, long term potentiation, cell motility, differentiation, secretion, and apoptosis. It has also been found that a number of neurodegenerative disorders have been attributed 2 1 to aberrations of intracellular Ca + homeostasis. 2 2 Intracellular Ca + levels and Ca + signaling within cells must 2 3 2 be tightly controlled. * Ca + overload as a result of seizures or ischemia is supposed to activate biochemical processes, leading to enzymatic breakdown of proteins and lipids, malfunctioning of 2 mitochondria, energy failure and ultimately cell death. There is 3 experimental evidence that electrically induced irreversible depo- larization of hippocampal neurons, which may be an early indica- 2 tion of neuronal damage, could be prevented by injecting Ca + chelators and thereby increasing intracellular buffering capacity. Thus, it is reasonable to assume that neurons containing certain 2 intracellular Ca +-binding proteins, and therefore having a greater 2 capacity to buffer Ca +, could be more resistant to degeneration.

General

Imprint:	Springer-Verlag
Country of origin:	Germany
Series:	Neuroscience Intelligence Unit
Release date:	November 2013
First published:	1995
Authors:	Claus W Heizmann • Katharina Braun
Dimensions:	254 x 178 x 9mm (L x W x T)
Format:	Paperback
Pages:	139
Edition:	Softcover reprint of the original 1st ed. 1995
ISBN-13:	978-3-662-21691-0
Categories:	Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Neurosciences Books > Science & Mathematics > Biology, life sciences > Biochemistry > General
LSN:	3-662-21691-4
Barcode:	9783662216910

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