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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Genetics (non-medical)
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Mouse as a Model Organism - From Animals to Cells (Paperback, 2011 ed.)
Loot Price: R4,315
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Mouse as a Model Organism - From Animals to Cells (Paperback, 2011 ed.)
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Cell culture based research is important for our understanding of
biological processes at the cellular and molecular level. Using
this approach, the previous decades have produced a wealth of
mechanistic information in all areas of biomedical research. Such
in vitro research, however, lacks the complexity of in vivo
investigations, where many different cell types interact with each
other in a normal, three-dimensional environment, with normal
levels of cytokines and growth factors. Furthermore, complex human
diseases, such as cancer, diabetes or chronic inflammation, can
only be modeled in vivo. Due to its small size, its short
reproduction time, and the possibility to introduce specific gene
mutations, the mouse has become the favourite mammalian model
organism to study in vivo function of genes during development and
in disease. This book combines review articles on selected subjects
presented at the symposium "Mouse as a Model Organism - From
Animals to Cells", held in Rovaniemi, Finland, 2009. Among other
topics, high-throughput phenotyping of mouse mutants, mouse
phenotypes dependent on nature and nuture, and a spectrum of in
vivo, ex vivo and in vitro methods to study cancer in mice are
described. This book will give an excellent introduction to
scientists interested in the use of mice as a model to understand
complex biological questions in the post-genomic era. It will
highlight the possibilities, but also discuss the current problems
and shortcomings, to give a realistic view of the current
state-of-art in this fascinating field of biomedical research.
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