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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Applications of Mass Spectrometry in Life Safety (Hardcover, 2008 ed.)
Loot Price: R4,377
Discovery Miles 43 770
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Applications of Mass Spectrometry in Life Safety (Hardcover, 2008 ed.)
Series: NATO Science for Peace and Security Series A: Chemistry and Biology
Expected to ship within 10 - 15 working days
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Mass spectrometry (MS) along with its hyphenated techniques is
capable of high throughput, sensitivity, accuracy and selectivity
for the analysis of structure and composition of almost any
product. Like in electrophoresis, MS separates mo- cules based on
the mass-to-charge ratio. In case of gel electrophoresis (SDS-
PAGE), a well-known and efficient bioanalytical technique, proteins
bear negative charges but have the same charge density, so proteins
are separated according to their size. Similarly, in case of MS
analysis, proteins carry the same charge, and are separated by
their molecular weight. Unlike SDS-PAGE, however, modern ultra high
resolution MS discerns very small mass differences and can resolve
and completely identify in a single experiment species of the same
nominal mass in complex biological mixtures. Consequently, MS can
be used for the structural characterization, identification and
sensitive detection of mixtures of biomolecules or for assessing
the quality of isolated proteins (purity, integrity, or
post-translational modifications, for example), carbohydrates,
nucleic acids, drugs, metabolites, pollutants etc. In the
post-genome era, MS is continuously developing as one of the most
re- able analytical method for elucidating the structure of
molecules originating from various biological matrices. The
potential of MS for high-sensitive structural a- lyses became
unsurpassable after the introduction of electrospray (ESI) and
matrix assisted laser/desorption ionization (MALDI) methods, on one
hand, and the pos- bility to deduce in detail unknown biopolymer
structures by highly accurate mo- cular mass measurement followed
by sequencing using dissociation techniques based on multiple stage
MS, on the other.
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