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Cell Death - The Role of PARP (Hardcover)
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Cell Death - The Role of PARP (Hardcover)
Series: Handbooks in Pharmacology and Toxicology
Expected to ship within 12 - 17 working days
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Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose)
synthetase (PARS) is a nuclear enzyme with a wide range of
functions, including regulation of DNA repair, cell
differentiation, and gene expression. More than a decade after the
identification of PARP-like enzymatic activities in mammalian
cells, a novel role was proposed for this enzyme, mediating a
suicidal mechanism triggered by DNA strand breakage. This
hypothesis has since become a controversial centerpiece of the PARP
field, with many experimental systems both confirming and extending
the PARP suicide theory. Theoretical and practical implications of
the PARP suicide pathway were not extensively exploited until the
1990s. Researchers, for example, discovered a variety of findings;
among them, that nitric oxide can activate a pathway leading to
cell death (Neuronal cell death and pancreatic cell death), and
that peroxynitrite, a reactive oxidant species produced from the
reaction of nitric oxide and superoxide free radicals, is an
endogenously produced trigger of DNA single strand breakage and
PARP activation. Featuring contributions from researchers in the
diverse fields of neuroinjury, myocardial injury, diabetes, shock,
and inflammation, this text examines the current status of the
field of PARP and cell death. Cell Death: The Role of PARP also
explores PARP and apoptosis, PARP and DNA repair, as well as PARP
and regulation of gene expression. Separate chapters focus on
developments in the areas of pharmacological inhibition of PARP and
on novel ways of measuring PARP activation. Furthermore, the
emerging field of PARP isoforms is addressed. While tremendous
progress has been made in the area of PARP and celldeath, many
controversies need to be clarified, and recent discoveries and
observations require further development. Cell Death: The Role of
PARP not only presents a state-of-the-art overview of the field,
but serves as a catalyst for further research in this area.
General
Imprint: |
Crc Press
|
Country of origin: |
United States |
Series: |
Handbooks in Pharmacology and Toxicology |
Release date: |
June 2000 |
First published: |
2000 |
Editors: |
Csaba Szabo
|
Dimensions: |
234 x 156 x 25mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
352 |
ISBN-13: |
978-0-8493-2267-9 |
Categories: |
Books >
Science & Mathematics >
Biology, life sciences >
General
|
LSN: |
0-8493-2267-7 |
Barcode: |
9780849322679 |
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