This work presents current knowledge of the molecular genetics of
the protein factors relevant to venous thrombotic disease, and
describes the molecular basis of the various known deficiency
states. It brings together all the relevant information required
for the identification, study and analysis of the underlying
gene/protein defects. It covers protein structure, function and
biochemistry, gene structure and expression, as well as
epidemiological and molecular aspects of the deficiency state.
Molecular models of the proteins and their dysfunctional variants
are presented wherever possible.
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