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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Immunology
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The CD4 Molecule - Roles in T Lymphocytes and in HIV Disease (Paperback, Softcover reprint of the original 1st ed. 1996)
Loot Price: R2,845
Discovery Miles 28 450
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The CD4 Molecule - Roles in T Lymphocytes and in HIV Disease (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Current Topics in Microbiology and Immunology, 205
Expected to ship within 10 - 15 working days
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During the late 1970's the application of hybridoma technology led
to an explosion in the discovery and characterization of proteins
expressed at the surface of hematopoietic cells. The understanding
of T lymphocyte biology benefited enormously from this advance and
from newly developed techniques for obtaining clonal T cells.
Application of these methodologies resulted in the identification
of the clonally restricted T cell antigen receptors (TCRs) and of a
number of other molecules expressed more broadly on T cells. Among
these, the CD4 and CD8 glycoproteins stood out because they were
differentially expressed on distinct functional subsets of T
lymphocytes. Moreover, blocking studies with monoclonal antibodies
sug gested a functional role for CD4 and CD8 in T cell responses to
antigen. Shortly thereafter, it was shown that T helper cells were
the primary targets for the human immunodeficiency virus (HIV) and
that CD4 serves as the viral receptor on these cells. These
findings fueled an intense interest in CD4 during the last decade,
in the hope that understanding the molecular nature of the HIV-CD4
interaction could hold the key to controlling AIDS.
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