Advances in genetics are transforming estimates of an individual
's risk of developing cancer and approaches to prevention and
management of cancer in those who may have increased
susceptibility. Identifying and caring for patients with hereditary
cancer syndromes and their family members present a complex
clinical, scientific and social challenge. This textbook, by
leading experts at Massachusetts General Hospital Cancer Center,
highlights the current understanding of the genetics of hereditary
cancers of the breast, ovary, colorectum, stomach, pancreas,
kidney, skin, and endocrine organs. Practical guidelines for the
use of genetic testing, cancer screening and surveillance,
prophylactic surgery, and promising targeted therapeutic agents are
discussed.
In addition, ongoing research involving genome-wide screens to
identify novel modest risk-associated genetic loci are explored,
along with new approaches to the application of genetic markers in
guiding therapeutic options.
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