This volume explores the mechanisms of resistance to targeted
therapeutics. The focus is on the cancer cell signaling network,
although other mechanisms of resistance including target mutation,
and new areas of study such as cancer stem cells are included.
Targeted Therapies: Mechanisms of Resistance highlights examples of
changes in the signaling network in response to inhibition of a
signaling event and underscores the importance in having a
mechanistic understanding of the signaling network in cancer for
developing effective targeted cancer therapies. Moreover, cutting
edge tools to analyze the cell signaling network will be discussed.
This includes the leading edge of techniques as well as
computational biology and systems theory. This volume provides the
reader with both an overview as well as a detailed perspective on
the mechanisms of resistance to targeted therapeutics and will be
of great value to the oncologist, the physician-scientist treating
patients and the translational scientist working on any aspect of
targeted therapeutics.
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