0
Your cart

Your cart is empty

Books > Science & Mathematics > Biology, life sciences > Cellular biology

Buy Now

Senolytics in Disease, Ageing and Longevity (Hardcover, 1st ed. 2020) Loot Price: R4,135
Discovery Miles 41 350
Senolytics in Disease, Ageing and Longevity (Hardcover, 1st ed. 2020): Daniel Munoz-Espin, Marco Demaria

Senolytics in Disease, Ageing and Longevity (Hardcover, 1st ed. 2020)

Daniel Munoz-Espin, Marco Demaria

Series: Healthy Ageing and Longevity, 11

 (sign in to rate)
Loot Price R4,135 Discovery Miles 41 350 | Repayment Terms: R388 pm x 12*

Bookmark and Share

Expected to ship within 12 - 17 working days

This book offers comprehensive information on the new and rapidly evolving science of identifying and targeting senescent cells, and on the exciting prospect of new diagnostic and therapeutic opportunities for stopping, and even reversing, the progression of disease and the deterioration of the human body due to ageing. According to recent United Nations data, by 2050 one in six people worldwide will be older than age 65, with peaks rising to one in four people in Europe and North America. Remarkably, the number of persons aged 80 years or older is expected to triple, from 143 million in 2019 to 426 million in 2050. First documented in the 1960s, the concept of cellular senescence as an underlying cause of ageing has been established in the course of the last decade. Using genetically engineered mouse models, researchers have demonstrated that the selective elimination of senescent cells can block and even reverse a number of age-related dysfunctions and pathologies, promoting both better health and longer life in the elderly. These include cardiovascular diseases; neurological disorders; type 1 and type 2 diabetes; inflammatory diseases; fibrosis; geriatric syndromes; chronic diseases resulting in organ dysfunction; the integrity of the musculoskeletal system; and cancer. Some senolytic agents have already progressed into trials. These include UBX0101 for the treatment of osteoarthritis (now in phase II), a cocktail of dasatinib and quercetin for the management of idiopathic pulmonary fibrosis and chronic kidney disease, and ABT-263 in combination with senescence-inducing chemotherapies for the treatment of advanced solid tumours. In addition, the book discusses pathways to early phase clinical trials and translational approaches in medicine and ageing, highlighting new opportunities as well as current limitations, challenges and alternatives. Given its scope, it will benefit a broad audience of advanced educators, researchers, graduate students and practitioners.

General

Imprint: Springer Nature Switzerland AG
Country of origin: Switzerland
Series: Healthy Ageing and Longevity, 11
Release date: April 2020
First published: 2020
Editors: Daniel Munoz-Espin • Marco Demaria
Dimensions: 235 x 155mm (L x W)
Format: Hardcover
Pages: 222
Edition: 1st ed. 2020
ISBN-13: 978-3-03-044902-5
Categories: Books > Science & Mathematics > Biology, life sciences > Developmental biology
Books > Medicine > General issues > Medical equipment & techniques > Medical research
Books > Science & Mathematics > Biology, life sciences > Cellular biology > General
Books > Science & Mathematics > Biology, life sciences > Zoology & animal sciences > Animal pathology & diseases
Promotions
LSN: 3-03-044902-5
Barcode: 9783030449025

Is the information for this product incomplete, wrong or inappropriate? Let us know about it.

Does this product have an incorrect or missing image? Send us a new image.

Is this product missing categories? Add more categories.

Review This Product

No reviews yet - be the first to create one!

You might also like..

The Song Of The Cell - The Story Of Life
Siddhartha Mukherjee Paperback R398 R334 Discovery Miles 3 340
Encyclopedia of Cell Biology
Ralph A. Bradshaw, Philip D. Stahl, … Hardcover R63,427 Discovery Miles 634 270
Cellular Senescence in Disease
Manuel Serrano, Daniel Munoz-Espin Paperback R3,160 Discovery Miles 31 600
Encyclopedia of Respiratory Medicine
Sam Janes Hardcover R77,529 Discovery Miles 775 290
Membranes in Pulmonary Vascular Disease…
Patrick Belvitch, Steven Dudek Hardcover R4,578 Discovery Miles 45 780
Biology of T Cells - Part A, Volume 341
Lorenzo Galluzzi, Nils-Petter Rudqvist Hardcover R5,322 Discovery Miles 53 220
Cell Volume Regulation, Volume 81
Irena Levitan, Eric Delpire, … Hardcover R4,620 Discovery Miles 46 200
Darwin's Pangenesis and Its Rediscovery…
Dhavendra Kumar Hardcover R3,845 Discovery Miles 38 450
Microfluidics in Cell Biology: Part A…
Matthieu Piel, Daniel Fletcher, … Hardcover R4,505 Discovery Miles 45 050
G Protein-Coupled Receptors: Emerging…
Arun K. Shukla Hardcover R5,296 Discovery Miles 52 960
Therapeutic Proteins and Peptides…
Rossen Donev Hardcover R3,876 Discovery Miles 38 760
Advances in Applied Microbiology, Volume…
Geoffrey M. Gadd, Sima Sariaslani Hardcover R3,205 Discovery Miles 32 050

See more

Partners