Stereoselective Heterocycle Synthesis via Alkene Difunctionalization - Bulky Phosphine Ligands Enable Pd-Catalyzed Arylhalogenation, Arylcyanation and Diarylation (Hardcover, 1st ed. 2018)

This book investigates the use of palladium modified by bulky ligands as catalysts for new chemical transformations that rapidly assemble several classes of complex heterocyles. It documents the development of new chemical reactions involving carbon-carbon (C-C) and carbon-halogen (C-X) bond formation in the context of alkene difunctionalization and dearomatization reactions. Due to the ubiquity of heterocycles in bioactive natural products and life-improving pharmaceutical treatments, a long-term goal for synthetic organic chemists has been to develop novel and creative heterocycle syntheses that illicit a high degree of product diversity and are characterized by mild reaction conditions and limited waste production. A considerable fraction of leading pharmaceutical drugs contain at least one heterocycle within their chemical structure, and their prevalence in these technologies is strong evidence that the fundamental curiosities of organic chemistry lead to real-world solutions for the health and wellness of the global population.

General

Imprint:	Springer International Publishing AG
Country of origin:	Switzerland
Series:	Springer Theses
Release date:	April 2018
First published:	2018
Authors:	David A. Petrone
Dimensions:	235 x 155mm (L x W)
Format:	Hardcover
Pages:	365
Edition:	1st ed. 2018
ISBN-13:	978-3-319-77506-7
Categories:	Books > Science & Mathematics > Chemistry > Organic chemistry > Organometallic chemistry Books > Science & Mathematics > Chemistry > Physical chemistry > Catalysis Books > Science & Mathematics > Biology, life sciences > Biochemistry > General Promotions
LSN:	3-319-77506-5
Barcode:	9783319775067

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