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Gliomas - Classification, Symptoms, Treatment & Prognosis (Hardcover)
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Gliomas - Classification, Symptoms, Treatment & Prognosis (Hardcover)
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Gliomas represent some of the most difficult tumours to understand
and most challenging to treat. As illustrated in this book, the
difficulty in understanding them is apparent in various ways. They
have significant diversity in histology, genomic alternations,
protein expression, clinical presentation, radiographic appearance,
treatment approaches, and ideas of how to cure them. Our current
understanding of the genetic mutations and signalling pathways that
drive these tumours has greatly expanded our knowledge and at the
same time, our uncertainty about how to combat these tumours. Added
to this complexity is the fact that we are typically talking about
tumours that infiltrate through an organ that many of us consider
the "seat of our souls," where we must exercise the utmost caution
in how we deliver treatments with great risks. This book begins
with an introduction to this complex topic with a broad overview of
grading criteria, histological features, common genomic alterations
and affected signalling pathways, and current treatments. Most
exciting is an extensive discussion on new therapeutic concepts and
delivering mechanisms that arise from the complex field of
nanotechnology where nanoparticles, nanotubes, and nanocrystals may
someday become the Trojan horse.
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