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Basic Mutagenicity Tests - UKEMS Recommended Procedures (Paperback, Revised)
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Basic Mutagenicity Tests - UKEMS Recommended Procedures (Paperback, Revised)
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This volume provides a brief but important summary of the essential
tests that need to be performed on all new compounds--whether they
are new drugs, pesticides or food additives--before they can be
registered for use in the United Kingdom. These basic tests for
mutagenicity, originally drawn up by the United Kingdom
Environmental Mutagen Society in 1983 have now been fully revised
under the auspices of expert working groups from academia and
industry and in collaboration with the UK Department of Health.
This volume therefore provides the latest official guidelines and
recommendations for all scientists involved in the testing and
registration of new compounds not only in the UK, but in wider
international context. The four main test procedures for measuring
mutagenicity described in this volume are bacterial mutation
assays, metaphase chromosome aberration assays in vitro, gene
mutation assays in cultured mammalian cells, and in vivo
cytogenetics assays. Each of these tests is fully explained and
described in practical and procedural detail, with additional
information on the presentation and data processing of results.
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