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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Cancer Cell Signaling - Methods and Protocols (Hardcover, 2003 ed.)
Loot Price: R3,064
Discovery Miles 30 640
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Cancer Cell Signaling - Methods and Protocols (Hardcover, 2003 ed.)
Series: Methods in Molecular Biology, 218
Expected to ship within 10 - 15 working days
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Cells respond to environmental cues through a complex and dynamic
network of signaling pathways that normally maintain a critical
balance between cellular proliferation, differentiation,
senescence, and death. One current research challenge is to
identify those aberrations in signal transd- tion that directly
contribute to a loss of this division-limited equilibrium and the
progression to malignant transformation. The study of
cell-signaling m- ecules in this context is a central component of
cancer research. From the knowledge of such targets, investigators
have been able to productively advance many insightful hypotheses
about how a particular cancer cell may misinterpret, or respond
inappropriately to, growth regulatory cues in their environment.
Despite these key insights, the rapidly evolving nature of cell
signaling research in cancer has necessitated a continuous revision
of these theoretical constructs and the updating of methods used in
their study. One contemporary example of the evolution of this
field is provided by an analysis of the Human Genome Project data,
which reveal a previously unsuspected diversity in the multigene
families encoding for most signaling pathway int- mediates. In
assessing the usefulness of a particular methodological approach,
therefore, we will need to keep in mind that there is a premium on
those p- tocols that can be easily adapted for the analysis of
multiple members within a gene family. Cancer Cell Signaling:
Methods and Protocols brings together several such methods in cell
signaling research that are scientifically grounded within the
cancer biology field.
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