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Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases (Paperback, 2009 ed.)
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Phagocytosis of Dying Cells - From Molecular Mechanisms to Human Diseases (Paperback, 2009 ed.)
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Phagocytosis has been at the forefront of cell biology for more
than a century. Initially, phagocytosis, which comes from Greek
words meaning "devouring cells," was discovered in the late 19th
century by Ilya Metchnikoff, who was awarded, together with Paul
Ehrlich, the Nobel Prize in Physiology and Medicine in 1908 "in
recognition of their work on immunity." At that time Metchnikoff
had already identified a function for phagocytes not only in host
defense but also as scavengers of degenerating host cells during
metamorphosis of tadpoles, thus providing one of the first
descriptions of apoptotic cell clearance by macrophages (Kaufmann
2008). Since then, much has been learned about phagocytosis, and
the previous several decades have witnessed outstanding progress in
understanding the functions and the molecular mechanisms of
phagocytosis. Two main types of targets are cleared by
phagocytosis: microbial pathogens and dying cells. Rapid
recognition and clearance of dying cells by phagocytes plays a
pivotal role in development, maintenance of tissue homeostasis,
control of immune responses, and resolution of inflammation.
Clearance of dying cells can be divided into several stages,
including sensing, r- ognition, binding and signaling,
internalization, and immunological responses. In this book, our
contributors address these different stages of dead cell cle- ance
and examine how impaired clearance of dying cells may lead to human
d- eases. We have attempted to provide sufficient cross-referencing
and indexing to enable the reader to easily locate the ideas
elaborated in the different chapters.
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