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Books > Medicine > Clinical & internal medicine > Neurology & clinical neurophysiology
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Neurobiology of Huntington's Disease - Applications to Drug Discovery (Hardcover)
Loot Price: R5,911
Discovery Miles 59 110
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Neurobiology of Huntington's Disease - Applications to Drug Discovery (Hardcover)
Series: Frontiers in Neuroscience
Expected to ship within 10 - 15 working days
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In 1993, the genetic mutation responsible for Huntington's disease
(HD) was identified. Considered a milestone in human genomics, this
discovery has led to nearly two decades of remarkable progress that
has greatly increased our knowledge of HD, and documented an
unexpectedly large and diverse range of biochemical and genetic
perturbations that seem to result directly from the expression of
the mutant huntingtin gene. Neurobiology of Huntington's Disease:
Applications to Drug Discovery presents a thorough review of the
issues surrounding drug discovery and development for the treatment
of this paradigmatic neurodegenerative disease. Drawing on the
expertise of key researchers in the field, the book discusses the
basic neurobiology of Huntington's disease and how its monogenic
nature confers enormous practical advantages for translational
research, including the creation of robust experimental tools,
models, and assays to facilitate discovery and validation of
molecular targets and drug candidates for HD. Written to support
future basic research as well as drug development efforts, this
volume: Covers the latest research approaches in genetics,
genomics, and proteomics, including high-throughput and
high-content screening Highlights advances in the discovery and
development of new drug therapies for neurodegenerative disorders
Examines the practical realities of preclinical testing, clinical
testing strategies, and, ultimately, clinical usage While the
development of effective drug treatments for Huntington's disease
continues to be tremendously challenging, a highly interactive and
cooperative community of researchers and clinical investigators now
brings us to the threshold of potential breakthroughs in the quest
for therapeutic agents. The impressive array of drug discovery
resources outlined in the text holds much promise for treating this
devastating disease, providing hope to long-suffering Huntington's
disease patients and their families.
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