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Books > Science & Mathematics > Biology, life sciences > Biochemistry
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Systems Pharmacology and Pharmacodynamics (Hardcover, 1st ed. 2016)
Loot Price: R7,156
Discovery Miles 71 560
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Systems Pharmacology and Pharmacodynamics (Hardcover, 1st ed. 2016)
Series: AAPS Advances in the Pharmaceutical Sciences Series, 23
Expected to ship within 12 - 17 working days
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While systems biology and pharmacodynamics have evolved in
parallel, there are significant interrelationships that can enhance
drug discovery and enable optimized therapy for each patient.
Systems pharmacology is the relatively new discipline that is the
interface between these two methods. This book is the first to
cover the expertise from systems biology and pharmacodynamics
researchers, describing how systems pharmacology may be developed
and refined further to show practical applications in drug
development. There is a growing awareness that pharmaceutical
companies should reduce the high attrition in the pipeline due to
insufficient efficacy or toxicity found in proof-of-concept and/or
Phase II studies. Systems Pharmacology and Pharmacodynamics
discusses the framework for integrating information obtained from
understanding physiological/pathological pathways (normal body
function system vs. perturbed system due to disease) and
pharmacological targets in order to predict clinical efficacy and
adverse events through iterations between mathematical modeling and
experimentation.
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