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The Essential Guide to Magnetic Resonance (Paperback)
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The Essential Guide to Magnetic Resonance (Paperback)
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The opening chapter of The Essential Guide to Magnetic Resonance
presents applications of Fluorine-19 Magnetic Resonance Imaging
(19F MRI) in cancer research, tissue metabolomics, quantification
of drug delivery, cellular tracking, tissue pH measurements and
detection of 19F labeled cells. The authors review in vitro
research applying 19F MRI and Magnetic Resonance Spectroscopy (MRS)
to facilitate the synthesis, tracking and visualization of new
fluorinated drug conjugates. 19F MRI also provides high contrast in
vivo images due to the absence of an endogenous 19F signal, 100%
natural abundance of 19F, and a chemical shift range of over 400
ppm. Afterwards, examples of current methods of magnetic resonance
imaging (MRI) guided photodynamic therapy are presented. Recent
development of MRI detectable nanoparticle constructs, magnetic
resonance spectroscopy (MRS) sensors, gadolinium based
photosensitizers and europium singlet oxygen probes are discussed.
In addition, applications of Functional MRI using a blood oxygen
dependent level (BOLD) MRI in monitoring photodynamic action are
addressed, with the goal of informing researchers about the
potential for using MRI guided photodynamic therapy and oxygen
dosimetry. The applications of MRI within the sphere of pharmacy
are analyzed; in particular, the use of MRI to track
pharmaceuticals in vitro and in vivo noninvasively and monitoring
their controlled-release. Functional MRI for noninvasive clinical
brain imaging is explored as it is applied to studies of autism,
schizophrenia, epilepsy Alzheimers disease, Parkinson's disease,
traumatic brain injury and blood oxygenation-level dependent (BOLD)
imaging of brain function. An overview of the scope of MRI as a
diagnostic technique in neurology and in neurosurgery is also
provided.
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