This issue of MRI Clinics of North America focuses on Imaging of the Foot and Ankle, and is edited by Dr. Mary Hochman. Articles will include: Technical Considerations: Best Practices for MR Imaging of the Foot and Ankle; Normal Variants and Potential Pitfalls in MRI of the Ankle and Foot; Medial Sided Ankle Pain: MRI of the Deltoid Ligament and Beyond; MRI of Impingement and Entrapment Syndromes of the Foot and Ankle; MRI of the Diabetic Foot; MRI of the Midfoot; MRI of the Plantar Plate: Normal Anatomy, Turf Toe, and other Injuries; MRI of Common Bone and Soft Tissue Tumors in the Foot and Ankle; MRI of the Post-operative Ankle and Foot; New Techniques in MR Imaging of the Ankle and Foot; MRI of the Pediatric Foot and Ankle: What Does Normal Look Like?; and more!

This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!

MRI of the Elbow and Wrist is explored in this important issue in MRI Clinics of North America. Articles include: Approach to MRI of the Elbow and Wrist: Technical Aspects and Innovation; MRI of the Elbow; Extrinsic and Intrinsic Ligaments of the Wrist; MRI of the Triangular Fibrocartilage Complex; Carpal Fractures; MRI of Tumors of the Upper Extremity; MRI of the Nerves of the Upper Extremity: Elbow to Wrist; MR Arthrography of the Wrist and Elbow; MRI of the Wrist and Elbow: What the Hand Surgeon Needs to Know; Imaging the Proximal and Distal Radioulnar Joints; MR Angiography of the Upper Extremity, and more!

Editor Hersh Chandarana, MD and authors review Advanced MR Imaging in Clinical Practice. Articles will include: Current Status of Diffusion Weighted Imaging; Current Status of Perfusion Weighted Imaging; Non-gadolinium Enhanced MR Angiography; Pearls and Pitfalls of 3 T imaging; Implementing MR Neurography in Clinical Practice; Imaging around Hardware and Metal; Recent Advances in T1- and T2-Weighted Imaging of the Abdomen and Pelvis; Recent Advances in Neuro and Spine Imaging; Advances in MR Hardware and Software, and more!

Cardiac MR is explored in this important issue in MRI Clinics of North America. Articles will include: MR physics in practice; Ventricular mechanics: Techniques and applications; MR safety issues particular to women; Novel MR applications for evaluation of pericardial diseases; 4D flow applications for aortic diseases; T1 mapping: technique and applications; ARVD: An updated imaging approach; Imaging the metabolic syndrome; Coronary MRA: how to optimize image quality; Prognostic role of MRI in nonischemic myocardial disease; MRI for valvular imaging; MRI for adult congenital heart disease assessment; Cardiac MRI applications for cancer patients; Applications of PET-MRI for cardiovascular disease; Rings and slings, and more.

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field.
Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomicsCurrent overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applicationsInformation about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

This third volume of NMR Spectroscopy in the Undergraduate Curriculum continues the work we started with the first and second volumes in providing effective approaches for using nuclear magnetic resonance spectrometers as powerful tools for investigating a wide variety of phenomena at the undergraduate level. This volume focuses on upper-level courses and NMR spectroscopy across the curriculum. The applications and strategies in this volume will be helpful to those who are looking to transform their curriculum by integrating more NMR spectroscopy, to those who might not have considered NMR spectroscopy as a tool for solving certain types of problems, or for those seeking funding for a new or replacement NMR spectrometer.

This indispensable guide gives concise yet comprehensive descriptions of the pulse sequences commonly used on modern MRI scanners. The book consists of a total of 65 self-contained sections, each focused on a single subject. Written primarily for scientists, engineers, radiologists, and graduate students who are interested in an in-depth understanding of various MRI pulse sequences, it serves readers with a diverse set of backgrounds by providing both non-mathematical and mathematical descriptions.
The book is divided into five parts. Part I of the book describes two mathematical tools, Fourier transforms and the rotating reference frame, that are useful for understanding MRI pulse sequences. The second part is devoted to a wide variety of radiofrequency (RF) pulses, and the third part focuses on gradient waveforms. Data acquisition, image reconstruction, and physiological monitoring related to pulse sequence design form the subject of Part IV of the book. Once this foundation is established, Part V of the book describes the underlying principles, implementation, and selected applications of many pulse sequences commonly in use today.
The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique.
-Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI
-Provides self-contained sections for individual techniques
-Can be used as a quick reference guide or as a resource for deeper study
-Includes both non-mathematical andmathematical descriptions
-Contains numerous figures, tables, references, and worked example problems

Breast MRI: State of the Art and Future Directions provides a comprehensive overview of the current applications of breast MRI, including abbreviated MRI, as well as presenting technical recommendations, practical implementation and associated challenges in clinical routine. In addition, the book introduces novel MRI techniques, multimodality imaging, and advanced image processing coupled with AI, reviewing their potential for impeding and future clinical implementation. This book is a complete reference on state-of-the-art breast MRI methods suitable for MRI researchers, radiographers and clinicians. Breast cancer is one of the leading causes of death among women with early detection being the key to improved prognosis and survival. Magnetic resonance imaging (MRI) of the breast is undisputedly the most sensitive imaging method to detect cancer, with a higher detection rate than mammography, digital breast tomosynthesis, and ultrasound.

Magnetic Resonance Imaging: Recording, Reconstruction and Assessment gives a detailed overview of magnetic resonance imaging (MRI), along with its applications and challenges. The book explores the abnormalities in internal human organs using MRI techniques while also featuring case studies that illustrate measures used. In addition, it explores precautionary measures used during MRI based imaging, the selection of appropriate contrast agents, and the selection of the appropriate modality during the image registration. Sections introduce medical imaging, the use of MRI in brain, cardiac, lung and kidney detection, and also discuss both 2D and 3D imaging techniques and various MRI modalities. This volume will be of interest to researchers, engineers and medical professionals involved in the development and use of MRI systems.

Quantitative Magnetic Resonance Imaging is a 'go-to' reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs

Magnetic Resonance Imaging of The Pelvis: A Practical Approach presents comprehensive information to deal with commonly encountered pelvic pathologies. The content is developed by disease-focused experts aiming to share their experience to make the information easily applicable to clinical setting and research. The book covers a wide range of pelvic pathologies, and each chapter focuses on problem-solving approaches and includes tips and advice for multiple real-world scenarios. It also provides comprehensive-yet-tailored protocols, clear guidelines for indications, a detailed discussion of pathologies, descriptions of important differential diagnoses, and pitfalls and their solutions. It is a valuable resource for radiologists, researchers, clinicians, and members of medical and biomedical fields who need to understand better how to use MRI to base their diagnosis or advance their research work.

In this issue of MRI Clinics, guest editor Dr. Luis Beltran brings his considerable expertise to the topic of Postoperative Joint MR Imaging. Postoperative imaging is key to evaluating healing, identifying postsurgical complications, and monitoring for indications of rejection. In this first-of-its-kind Clinics issue, top experts focus on postoperative imaging of the hip, knee, wrist, hand, rotator cuff, elbow, foot, and ankle. Contains 11 practice-oriented topics including technical considerations in postoperative MR joint imaging; postoperative MRI of the elbow; postoperative MRI of the hip; postoperative MRI of the knee ligaments; postoperative MRI of the ankle and foot; and more. Provides in-depth clinical reviews on postoperative joint MR imaging, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

In this issue of PET Clinics, guest editors Drs. Harshad R. Kulkarni and Abass Alavi bring their considerable expertise to the topic of Prostate Cancer. PET imaging for prostate cancer continues to evolve as new radiotracers and imaging modalities are combined. This issue offers an up-to-date review of the most popular radiotracers and how PET imaging is combined with MR, CT, and ultrasound to provide the most accurate diagnosis of prostate cancer. Contains 12 practice-oriented topics including the role of ultrasound, CT, and MRI in managing patients with prostate cancer; Ga68 PSMA imaging; PET imaging for prostate cancer using F-18 Fluciclovine; PET imaging for prostate cancer using Ga-68 RM2; the role of NaF PET in the imaging of prostate cancer; and more. Provides in-depth clinical reviews on prostate cancer, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Hyperpolarized and Inert Gas MRI: Theory and Applications in Research and Medicine is the first comprehensive volume published on HP gas MRI. Since the 1990's, when HP gas MRI was invented by Dr. Albert and his colleagues, the HP gas MRI field has grown dramatically. The technique has proven to be a useful tool for diagnosis, disease staging, and therapy evaluation for obstructive lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis. HP gas MRI has also been developed for functional imaging of the brain and is presently being developed for molecular imaging, including molecules associated with lung cancer, breast cancer, and Alzheimer's disease. Taking into account the ongoing growth of this field and the potential for future clinical applications, the book pulls together the most relevant and cutting-edge research available in HP gas MRI into one resource.

This issue of MRI Clinics of North America focuses on Advanced MR Techniques for Imaging the Abdomen and Pelvis and is edited by Dr. Sudhakar Venkatesh. Articles will include: Advances in MR Elastography in Liver; Biliary Tract Imaging; Imaging of the Pancreas; PET/MRI Applications in Abdomen and Pelvis; Abbreviated MR Protocols for the Abdomen and Pelvis; Advances in MR Angiography of Abdomen and Pelvis; Advances in MRI of Prostate; Advances in MRI of the Female Pelvis; Advanced MR Techniques for Imaging the Abdomen and Pelvis; Texture Analysis and AI with MR in Abdomen and Pelvis; Advances in MRI of the Kidneys and Upper Urinary Tract, and more!

This issue of MRI Clinics of North America focuses on Breast Cancer, and is edited by Dr. Jessica Leung. Articles will include: Breast MRI: Atlas of anatomy, physiology, pathophysiology, and BI-RADS lexicon; Neoadjuvant therapy monitoring, including inflammatory breast cancer; Breast MRI biopsy considerations: Technique, histologic upgrading, and radiologic-pathologic concordance; Breast MRI techniques and developments: 1.5 vs 3T, diffusion, fast MRI, PET-MRI, and other developing techniques; ACR Accreditation, Performance Metrics, Reimbursement, and Economic Considerations in Breast MRI; Screening: high-risk and dense breasts, especially compared with tomosynthesis and ultrasound; Extent of breast disease, especially compared with tomosynthesis and ultrasound, with special focus on nodal assessment; Problem-solving tool for imaging finding and clinical symptoms of breast cancer; MRI compared with contrast-enhanced mammography; MRI compared with molecular breast imaging; MRI compared with positron emission mammography; How does MRI help care for my breast cancer patient? Perspective of a surgical oncologist; How does MRI help care for my breast cancer patient? Perspective of a medical oncologist; How does MRI help care for my breast cancer patient? Perspective of a radiation oncologist; and more!

Spin Resonance Spectroscopy: Principles and Applications presents the principles, recent advancements and applications of nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) in a single multi-disciplinary reference. Spin resonance spectroscopic techniques through NMR and EPR are widely used by chemists, physicists, biologists and medicinal chemists. This book addresses the need for new spin resonance spectroscopy content while also presenting the principles, recent advancements and applications of NMR and EPR simultaneously. Ideal for researchers and students alike, the book provides a single source of NMR and EPR applications using a dynamic, holistic and multi-disciplinary approach.

This issue of MRI Clinics of North America focuses on Update on Imaging Contrast Agents, and is edited by Drs. Carlos Zamora, Mauricio Castillo, Richard Semelka. Articles will include: Historical Perspective of Imaging Contrast Agents; Current Radiographic Iodinated Contrast Agents; Contrast-enhanced Sonography; Myelography: From Lipid-based to Gadolinium-based Contrast Agents; Acute Allergic Reactions with Gadolinium-based Contrast Agents: Diagnosis and Treatment; Deposition and Chronic Toxicity of Gadolinium-based Contrast Agents; Managing Allergic Reactions to Contrast Agents; Safety of Contrast Material Use in Children; Molecular Imaging and Contrast Agents; Contrast Agents for MR Imaging: Gadolinium, Manganese, SPIO, Superparamagnetic Iron Platinum, and Oral Agents; Contrast-induced Nephropathy: Pathophysiology, Manifestations, Prevention, and Management; and more!

This issue of Neuroimaging Clinics of North America focuses on Functional Connectivity, and is edited by Dr. Jay Pillai. Articles will include: Applications of rs-fMRI to presurgical mapping: sensorimotor mapping; Dynamic functional connectivity methods; Machine learning applications to rs-fMRI analysis; Frequency domain analysis of rs-fMRI; Applications of rs-fMRI to epilepsy; Data-driven analysis methods for rs-fMRI; Applications of rs-fMRI to presurgical mapping: language mapping; Limitations of rs-fMRI in the setting of focal brain lesions; Applications of rs-fMRI to neuropsychiatric disease; Applications of rs-fMRI to Traumatic Brain Injury; Applications of rs-fMRI to neurodegenerative disease; Graph theoretic analysis of rs-fMRI; and more!

This issue of MRI Clinics of North America focuses on Imaging of the Female Pelvis, and is edited by Katherine Maturen. Articles will include: MR Imaging of Adnexal Mass Characterization; MR Imaging of Abnormal Placentation; MR Imaging of the Pelvic Floor; MR-Pathologic Correlation of Ovarian Neoplasms; MR Imaging of Benign Uterine Pathologies; MR Imaging for Gynecologic Brachytherapy; MR Imaging of Mullerian Fusion Anomalies; MR Imaging in Cervical Cancer; MR Imaging in Female Pelvic Emergencies; MR Imaging in Endometrial Cancer; MR Imaging of the Female Perineum; PET/MR in Gynecologic Oncology; MR Imaging of Vulvar and Vaginal Cancer; and more!

This issue of MRI Clinics of North America focuses on MR Imaging of the Spine, and is edited by Dr. Mario Muto. Articles will include: Diagnostic Approach to Pediatric Spin Pathology; Neuroimaging of Scoliosis and Sagittal Balance; Neuroimaging of the Degenerative Spine; Neuroimaging of Spinal Instability; Neuroimaging of the Traumatic Spine; Neuroimaging of Spine Infections; Neuroimaging of the Post Operative Spine; Neuroimaging of Spinal Canal Stenosis; Neuroimaging of Spinal Tumors, and more!

This issue of MRI Clinics of North America focuses on MR in the Emergency Room. Articles will include: MR Imaging of Stroke; MR Imaging of Acute Head and Neck Infections; Use of MR in the Evaluation of Cranial Trauma; MR of Spinal Emergencies; Emergency MR Imaging of Musculoskeletal Trauma; Use of MR in Non-traumatic Musculoskeletal Emergencies; MR Imaging of Abdominal Pain in Pregnancy; MR of Pelvic and Gastrointestinal Emergencies; Use of MR in Pediatric Emergencies; Use of MR in Pancreatico-Biliary Emergencies; and more!