Diffusion-weighted MR Imaging, Perfusion MR Imaging, and Diffusion Tensor Imaging provide information that is present in no other imaging modality. With Guest Editor Scott Reeder focusing on the body and Guest Editor Pratik Mukerjee exploring the neurological aspects of these three imaging modalities, this is a must-have resource for any radiologist involved in MR Imaging. It explores such subjects as: Diffusion weighted MR imaging in musculoskeletal radiology, Arterial Spin Labeled Perfusion Imaging, and Diffusion Tensor Imaging of Neurodegenerative Diseases.

This publication presents topics on a variety of MR imaging techniques and approaches for the range of body regions.

Cardiovascular magnetic resonance (CMR) has evolved into a first-line imaging tool for several cardiac pathologies over the past decade. It is continuing to evolve as new applications are found and old ones are refined. This issue has a dual focus. One aspect of focus is on the areas in which CMI is the best modality, such as assessment of cardiac morphology and cardiac function, evaluation of pericardial disease and intracardiac masses, and detection of coronary artery disease. The other focus is on areas in which the role of CMI is expanding, such as in the assessment of left and right ventricular diastolic function.

Topics include: MR Imaging of the Pediatric Bone Marrow; The growing skeleton: MR appearances of developing cartilage; Infectious and Inflammatory Disorders; MRI of Pediatric Trauma; MRI of Pediatric Arthritis; MR Imaging of Primary Bone Tumors and Tumor-like Conditions in Children; MR Imaging of soft tissue masses in children; The hip: MR imaging of uniquely pediatric disorders; The knee: MR imaging of uniquely pediatric disorders; The foot and ankle: MR imaging of uniquely pediatric disorders; MRI in Congenital and Acquired Disorders of the Pediatric Upper Extremity.

Hip Magnetic Resonance Imaging presents a basic yet comprehensive discussion of the role and use of MRI in the diagnosis and treatment of injuries and diseases of the hip, highlighting common concerns and procedures. Beginning with the principles of MRI and dGEMRIC and moving on to normal and abnormal hip anatomy, the focus shifts to the MRI techniques used in the detection of disease conditions of the hip, including labral disease, osteonecrosis, extra-articular conditions and cartilage damage. Chapters on the utilization of biochemical imaging biomarkers in the treatment of hip disorders round out the text. Written by experts in radiology and orthopedics and generously illustrated with MRI radiographs, this book will be an important reference work for clinicians in those fields, as well as practitioners of sports medicine and primary care physicians.

As a spectroscopic method, nuclear magnetic resonance (NMR) has seen spectacular growth, both as a technique and in its applications. Today's applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive coverage of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules, which is covered in two reports: NMR of Proteins and Nucleic Acids; and NMR of Carbohydrates, Lipids and Membranes. For those wanting to become rapidly acquainted with specific areas of NMR, Nuclear Magnetic Resonance provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an invaluable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading experts in their specialist fields, this series is designed to help the chemistry community keep current with the latest developments in their field. Each volume in the series is published either annually or biennially and is a superb reference point for researchers. www.rsc.org/spr

Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.
*Provides a crucial update of recent advances in imaging techniques
*Timely publication as subject of neuroimaging is a very "hot" area in both clinical epilepsy and basic neuroscience research
*Editors are well-respected in this field

This book caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.This book builds a means of knowledge transfer between the beginners and the experts in NMR as applied to all aspects of life sciences.

Based on the most novel approaches and cutting-edge clinical and scientific information regarding radionuclide imaging and therapies for neuroendocrine tumors, this clinical guidebook represents a unique collaborative effort between endocrinologists, nuclear physicians, oncologists, surgeons, physicists, radio-pharmacists and geneticists. It begins with the embryology, classification and molecular genetics of gastroenteropancreatic neuroendocrine tumors and carcinoids, chromaffin cell tumors, and MEN1- and MEN2-related tumors. Following a chapter on radiopharmaceuticals in neuroendocrine imaging, it turns to the physics and technology of current and cutting-edge radiology, including SPECT/CT and PET/CT and PET/MR. Discussing of radionuclide imaging covers the tumors mentioned above, as well as pulmonary and thymic neuroendocrine tumors and medullary thyroid carcinoma. A presentation of radionuclide therapies follows, including 131I-MIBG therapy, somatostatin receptor-based therapy, and alpha radionuclide therapy, as well as the role of nanoparticles. Comprehensive and up-to-date, Diagnostic and Therapeutic Nuclear Medicine for Neuroendocrine Tumors will assist and guide physicians who encounter patients with these conditions, either from a diagnostic or therapeutic standpoint, and particularly emphasizes the current and emerging medical devices and imaging and therapeutic options.

This volume discusses a variety of preclinical MRI methods and protocols to help technicians and researchers conduct studies in their respective fields. This book is organized into 7 parts: Part 1 covers the basics of MRI physics, relaxation, image contrast, and main acquisition sequences; Part 2 describes methodologies for diffusion, perfusion, and functional imaging; Part 3 looks at in vivo spectroscopy; Part 4 explores special MRI techniques that are less known in the field; Parts 5 and 6 discuss MRIs and MRSs in animal models of disease and the applications used to study them, and Part 7 looks at anesthesia and advanced contrast agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Preclinical MRI: Methods and Protocols is a valuable resource for researchers interested in expanding their knowledge in this developing field.

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes." For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes." For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes." For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.

Electron magnetic resonance spectroscopy is undergoing something akin to a renaissance that is attributable to advances in microwave circuitry and signal processing software. EPR: Instrumental Methods is a textbook that brings the reader up to date on these advances and their role in providing better experimental techniques for biological magnetic resonance. Chapters in this book guide the reader from basic principles of spectrometer design through the advanced methods that are providing new vistas in disciplines such as oximetry, imaging, and structural biology.
Key Features:
Spectrometer design, particularly at low frequencies (below X-band),
Design of spectrometer components unique to ENDOR and ESEEM,
Optimization of EMR spectrometer sensitivity spanning many octaves,
Algorithmic approach to spectral parameterization,
Application of Fourier Methods to polymer conformation, oximetry, and imaging.

This book offers a review of the normal histopathological anatomy, imaging techniques and diagnostic findings for a broad spectrum of clinical problems. It includes a classification of inflammatory syndromes previously described under several different terms. It is the first textbook to describe the imaging of all anterior chest wall disorders.

Essentials of Body MRI extensively covers the field, offering clear and detailed guidance on MRI as an invaluable tool for the primary diagnosis and problem solving of diseases of the body, including the abdomen, liver, pancreas, pelvis, heart, urinary tract, and great vessels. The beginning chapters focus on the physics, pulse sequences and other practical considerations related to body MR imaging to help the reader fully understand the imaging appearance of clinical disease. The remaining chapters discuss the clinical applications, with the topics spanning from the normal anatomic structures and diagnosis of abdominal, pelvic, cardiac and vascular diseases to the modality's role as a tool for solving diagnostic problems. The key points of each chapter are boxed as "Essentials to Remember" for rapid review and learning. Written in clear, accessible text, and featuring 887 figures and numerous tables, Essentials of Body MRI is a resource that the radiology resident and physician will turn to again and again.

Volume 17 is the second in a special topic series devoted to modern techniques in protein NMR, under the Biological Magnetic Resonance series. Volume 16, with the subtitle Modern Techniques in Protein NMR , is the first in this series. These two volumes present some of the recent, significant advances in the biomolecular NMR field with emphasis on developments during the last five years. We are honored to have brought together in these volume some of the world s foremost experts who have provided broad leadership in advancing this field. Volume 16 contains - vances in two broad categories: I. Large Proteins, Complexes, and Membrane Proteins and II. Pulse Methods. Volume 17 contains major advances in: I. Com- tational Methods and II. Structure and Dynamics. The opening chapter of volume 17 starts with a consideration of some important aspects of modeling from spectroscopic and diffraction data by Wilfred van Gunsteren and his colleagues. The next two chapters deal with combined automated assignments and protein structure determination, an area of intense research in many laboratories since the traditional manual methods are often inadequate or laborious in handling large volumes of NMR data on large proteins. First, Werner Braun and his associates describe their experience with the NOAH/DIAMOD protocol developed in their laboratory.

Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1-2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].

MRI has become an important tool in the management of patients with diseases of the gastrointestinal tract, such as rectal cancer and inflammatory bowel diseases. This book, written by distinguished experts in the field, discusses in detail the technical, practical, and clinical aspects of MRI of the gastrointestinal tract. The chapters on technique encompass the most recent developments and address such topics as contrast media, high field strength MRI, and perfusion MRI. Subsequently, individual chapters are devoted to the clinical applications of MRI in the different parts of the gastrointestinal tract. Both established applications and new frontiers are considered, with the aid of numerous high-quality illustrations. By combining chapters dedicated to technical aspects and clinically oriented chapters, this book will prove very instructive for the novice while simultaneously offering experienced practitioners further insights into the value of MRI of the gastrointestinal tract.

This book covers new techniques in protein NMR, from basic principles to state-of-the-art research. It covers a spectrum of topics ranging from a "toolbox" for how sequence-specific resonance assignments can be obtained using a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome. Further topics include the novel applications of Overhauser dynamic nuclear polarization methods (DNP), assessing protein structure, and aspects of solid-state NMR of macroscopically aligned membrane proteins. This book is an ideal resource for students and researchers in the fields of biochemistry, chemistry, and pharmacology and NMR physics. Comprehensive and intuitively structured, this book examines protein NMR and new novel applications that include the latest technological advances. This book also has the features of: * A selection of various applications and cutting-edge advances, such as novel applications of Overhauser dynamic nuclear polarization methods (DNP) and a suite of 2D and 3D NMR experiments and tips on how overlap problems can be overcome * A pedagogical approach to the methodology * Engaging the reader and student with a clear, yet critical presentation of the applications

The foundation for understanding the function and dynamics of biological systems is not only knowledge of their structure, but the new methodologies and applications used to determine that structure. This volume in Biological Magnetic Resonance emphasizes the methods that involve Ultra High Field Magnetic Resonance Imaging. It will interest researchers working in the field of imaging.

Distance measurements in biological systems by EPR The foundation for understanding function and dynamics of biological systems is knowledge of their structure. Many experimental methodologies are used for determination of structure, each with special utility. Volumes in this series on Biological Magnetic Resonance emphasize the methods that involve magnetic resonance. This volume seeks to provide a critical evaluation of EPR methods for determining the distances between two unpaired electrons. The editors invited the authors to make this a very practical book, with specific numerical examples of how experimental data is worked up to produce a distance estimate, and realistic assessments of uncertainties and of the range of applicability, along with examples of the power of the technique to answer biological problems. The first chapter is an overview, by two of the editors, of EPR methods to determine distances, with a focus on the range of applicability. The next chapter, also by the Batons, reviews what is known about electron spin relaxation times that are needed in estimating distances between spins or in selecting appropriate temperatures for particular experiments. Albert Beth and Eric Hustedt describe the information about spin-spin interaction that one can obtain by simulating CW EPR line shapes of nitroxyl radicals. The information in fluid solution CW EPR spectra of dual-spin labeled proteins is illustrated by Hassane Mchaourab and Eduardo Perozo.

This book presents a comprehensive treatment of electromagnetic analysis and design of three critical devices for an MRI system - the magnet, gradient coils, and radiofrequency (RF) coils. Electromagnetic Analysis and Design in Magnetic Resonance Imaging is unique in its detailed examination of the analysis and design of the hardware for an MRI system. It takes an engineering perspective to serve the many scientists and engineers in this rapidly expanding field.
Chapters present:
an introduction to MRI
basic concepts of electromagnetics, including Helmholtz and Maxwell coils, inductance calculation, and magnetic fields produced by special cylindrical and spherical surface currents
principles for the analysis and design of gradient coils, including discrete wires and the target field method
analysis of RF coils based on the equivalent lumped-circuit model as well as an analysis based on the integral equation formulation
survey of special purpose RF coils
analytical and numerical methods for the analysis of electromagnetic fields in biological objects
With the continued, active development of MRI instrumentation, Electromagnetic Analysis and Design in Magnetic Resonance Imaging presents an excellent, logically organized text - an indispensable resource for engineers, physicists, and graduate students working in the field of MRI.

This issue of MRI Clinics focuses on Advances in Diffusion-weighted Imaging and is edited by Dr. Kei Yamada. Articles will include: Technical Basics of Diffusion-weighted Imaging; Neurofluid as Assessed by Diffusion-weighted Imaging; Diffusion-weighted Imaging is the Key to Diagnoses; Diffusion-weighted Imaging of the Spinal Cord; Intracranial Abnormalities with Diffusion Restriction; Brain Anatomy by Diffusion-weighted Imaging; Measuring Perfusion: Intravoxel Incoherent Motion; Temperature Measurement by Diffusion-weighted Imaging; Diffusion-weighted Imaging at Ultra-high Field MRI; Diffusion-weighted Imaging for Radiomics; Diffusion Weighted Imaging for Infants; Diffusion-weighted Imaging of the Head and Neck (Including Temporal Bone); DTI, DKI and Q-space Imaging; and more!

In the past few decades, Magnetic Resonance Imaging (MRI) has become an indispensable tool in modern medicine, with MRI systems now available at every major hospital in the developed world. But for all its utility and prevalence, it is much less commonly understood and less readily explained than other common medical imaging techniques. Unlike optical, ultrasonic, X-ray (including CT), and nuclear medicine-based imaging, MRI does not rely primarily on simple transmission and/or reflection of energy, and the highest achievable resolution in MRI is orders of magnitude smaller that the smallest wavelength involved. In this book, MRI will be explained with emphasis on the magnetic fields required, their generation, their concomitant electric fields, the various interactions of all these fields with the subject being imaged, and the implications of these interactions to image quality and patient safety. Classical electromagnetics will be used to describe aspects from the fundamental phenomenon of nuclear precession through signal detection and MRI safety. Simple explanations and Illustrations combined with pertinent equations are designed to help the reader rapidly gain a fundamental understanding and an appreciation of this technology as it is used today, as well as ongoing advances that will increase its value in the future. Numerous references are included to facilitate further study with an emphasis on areas most directly related to electromagnetics.