MR is a powerful modality. At its most advanced, it can be used not just to image anatomy and pathology, but to investigate organ function, to probe in vivo chemistry, and even to visualise the brain thinking. However, clinicians, technologists and scientists struggle with the study of the subject. The result is sometimes an obscurity of understanding, or a dilution of scientific truth, resulting in misconceptions. This is why MRI from Picture to Proton has achieved its reputation for practical clarity. MR is introduced as a tool, with coverage starting from the images, equipment and scanning protocols and traced back towards the underlying physics theory. With new content on quantitative MRI, MR safety, multi-band excitation, Dixon imaging, MR elastography and advanced pulse sequences, and with additional supportive materials available on the book's website, this new edition is completely revised and updated to reflect the best use of modern MR technology.

Much MRI literature assumes that the reader is conversant with the specialised terms that have developed with the subject. For beginners this is often not the case, and this false assumption may hinder the reader's assimilation of information. The aim of this glossary is to explain these terms in plain language without assuming that the reader has a Ph.D. in physics!

This book presents a comprehensive treatment of electromagnetic analysis and design of three critical devices for an MRI system - the magnet, gradient coils, and radiofrequency (RF) coils. Electromagnetic Analysis and Design in Magnetic Resonance Imaging is unique in its detailed examination of the analysis and design of the hardware for an MRI system. It takes an engineering perspective to serve the many scientists and engineers in this rapidly expanding field.
Chapters present:
an introduction to MRI
basic concepts of electromagnetics, including Helmholtz and Maxwell coils, inductance calculation, and magnetic fields produced by special cylindrical and spherical surface currents
principles for the analysis and design of gradient coils, including discrete wires and the target field method
analysis of RF coils based on the equivalent lumped-circuit model as well as an analysis based on the integral equation formulation
survey of special purpose RF coils
analytical and numerical methods for the analysis of electromagnetic fields in biological objects
With the continued, active development of MRI instrumentation, Electromagnetic Analysis and Design in Magnetic Resonance Imaging presents an excellent, logically organized text - an indispensable resource for engineers, physicists, and graduate students working in the field of MRI.

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field.
Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomicsCurrent overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applicationsInformation about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

The detection and measurement of the dynamic interactions of proteins within the living cell are critical to our understanding of cell physiology and pathophysiology. With FRET microscopy and spectroscopy techniques, basic and clinical scientists can make such measurements at very high spatial and temporal resolution. But sources of background information about these tools are very limited, so this book fills an important gap. It covers both the basic concepts and theory behind the various FRET microscopy and spectroscopy techniques, and the practical aspects of using the techniques and analyzing the results. The critical tricks for obtaining a good FRET image and precisely quantitating the signals from living specimens at the nanomolecular level are explained. Valuable information about the preparation of biological samples used for FRET image analysis is also provided.
The methods covered include different types of microscopy systems and detectors (wide-field, confocal, multi-photon) as well as specialized techniques such as photobleaching FRET, FLIM-FRET microscopy, spectral imaging FRET, single molecule FRET, and time and image correlation spectroscopy. Starting from the basics, the chapters guide readers through the choice of probes to be used for FRET experiments and the selection of the most suitable experimental approaches to address specific biological questions. Up-to-date, consistently organized, and well-illustrated, this unique book will be welcomed by all researchers who wish to use FRET microscopy and spectroscopy techniques.

This indispensable guide gives concise yet comprehensive descriptions of the pulse sequences commonly used on modern MRI scanners. The book consists of a total of 65 self-contained sections, each focused on a single subject. Written primarily for scientists, engineers, radiologists, and graduate students who are interested in an in-depth understanding of various MRI pulse sequences, it serves readers with a diverse set of backgrounds by providing both non-mathematical and mathematical descriptions.
The book is divided into five parts. Part I of the book describes two mathematical tools, Fourier transforms and the rotating reference frame, that are useful for understanding MRI pulse sequences. The second part is devoted to a wide variety of radiofrequency (RF) pulses, and the third part focuses on gradient waveforms. Data acquisition, image reconstruction, and physiological monitoring related to pulse sequence design form the subject of Part IV of the book. Once this foundation is established, Part V of the book describes the underlying principles, implementation, and selected applications of many pulse sequences commonly in use today.
The extensive topic coverage and cross-referencing makes this book ideal for beginners learning the building blocks of MRI pulse sequence design, as well as for experienced professionals who are seeking deeper knowledge of a particular technique.
-Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI
-Provides self-contained sections for individual techniques
-Can be used as a quick reference guide or as a resource for deeper study
-Includes both non-mathematical andmathematical descriptions
-Contains numerous figures, tables, references, and worked example problems

The first book to introduce X-nuclei MRI to researchers, clinicians and students who are interested in working on the development of an imaging method to assess new metabolic information in tissues in vivo, to help diagnose diseases, to improve prognosis, or to assess the efficiency of therapies in a timely and quantitative manner. A comprehensive overview of the state-of-the-art in X-nuclei MRI, with its many potential clinical applications, but also its limitations. The ideal starting point for a clinical or scientific research project in non-standard MRI techniques. Illustrated throughout with excellent figures, references and reading suggestions to accompany each section.

Over the last decade, some of the greatest achievements in the field of neuroimaging have been related to remarkable advances in magnetic resonance techniques, including diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. Such techniques have provided valuable insights into tissue microstructure, microvasculature, metabolism and brain connectivity. Previously available mostly in research environments, these techniques are now becoming part of everyday clinical practice in a plethora of clinical MR systems. Nevertheless, despite growing interest and wider acceptance, there remains a lack of a comprehensive body of knowledge on the subject, exploring the intrinsic complexity and physical difficulty of the techniques. This book focuses on the basic principles and theories of diffusion, perfusion, magnetic resonance spectroscopy, and functional MRI. It also explores their clinical applications and places emphasis on the associated artifacts and pitfalls with a comprehensive and didactic approach. This book aims to bridge the gap between research applications and clinical practice. It will serve as an educational manual for neuroimaging researchers and radiologists, neurologists, neurosurgeons, and physicists with an interest in advanced MR techniques. It will also be a useful reference text for experienced clinical scientists who wish to optimize their multi-parametric imaging approach.

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 200 interactive brain imaging cases deliver the best board review possible! Part of McGraw-Hill's Radiology Case Review Series, this unique resource challenges you to look at a group of images, determine the diagnosis, answer related questions, and gauge your knowledge by reviewing the answer. It all adds up to the best review of brain imaging imaging available-one that's ideal for certification or recertification, or as an incomparable clinical refresher. Distinguished by a cohesive 2-page design, each volume in this series is filled with cases, annotated images, questions & answers, pearls, and relevant literature references that will efficiently prepare you for virtually any exam topic. Radiology and neurology residents and fellows, medical students, radiologists, and physicians who want to increase their knowledge of brain imaging will find this book to be an invaluable study partner.

Now entering its fourth edition, the market-leading Handbook of MRI Technique has been fully revised and updated to incorporate new technologies and developments essential to good practice. Written specifically for technologists and highly illustrated, it guides the uninitiated through scanning techniques and helps more experienced technologists to improve image quality. The first part of the book considers the main aspects of theory that relate to scanning and also includes practical tips on gating, equipment use, patient care and safety, and information on contrast media. The second half provides step-by-step instruction for examining each anatomical area, beginning with a basic anatomy section followed by sections on indications, patient positioning, equipment, artefacts and tips on optimizing image quality. Written by an international team of technologists from the United States, United Kingdom and Europe Suitable for users for all types of MRI systems Now includes key points throughout for quick reference Companion website at www.wiley.com/go/westbrook/mritechnique with self-assessment and image flashcards Handbook of MRI Technique continues to be the ideal support both for radiographers new to MRI and for regular users looking for information on alternative techniques and suggestions on protocol modifications.

"During the last two decades, new developments in functional MRI (magnetic resonance imaging) have made it possible to detect changes in the brain over time, as opposed to the "snapshot" produced by conventional MRI. Essentials of Functional MRI breaks down the technical challenges for physicians, researchers, and technologists who use functional MRI but may not be experts in the necessary math and physics. The author describes the theory and practical details of functional MRI (fMRI) methodology, including how to acquire and analyze images, and a wide range of examples demonstrate how fMRI has been used thus far. The author provides the essential information to study, understand, use, and teach the practical aspects of fMRI for those people who are most likely to extend its use into clinical practice"--Provided by publisher.

Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications. The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study. Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

Magnetic resonance imaging (MRI) is a technique used in biomedical imaging and radiology to visualize internal structures of the body. Because MRI provides excellent contrast between different soft tissues, the technique is especially useful for diagnostic imaging of the brain, muscles, and heart. In the past 20 years, MRI technology has improved significantly with the introduction of systems up to 7 Tesla (7 T) and with the development of numerous post-processing algorithms such as diffusion tensor imaging (DTI), functional MRI (fMRI), and spectroscopic imaging. From these developments, the diagnostic potentialities of MRI have improved impressively with an exceptional spatial resolution and the possibility of analyzing the morphology and function of several kinds of pathology. Given these exciting developments, the Magnetic Resonance Imaging Handbook: Image Principles, Neck, and the Brain is a timely addition to the growing body of literature in the field. Covering MRI from fundamentals to practice, this comprehensive book: Discusses the clinical benefits of diagnosing human pathologies using MRI Explains the physical principles of MRI and how to use the technique correctly Highlights each organ's anatomy and pathological processes with high-quality images Examines the protocols and potentialities of advanced MRI scanners such as 7 T systems Includes extensive references at the end of each chapter to enhance further study Thus, the Magnetic Resonance Imaging Handbook: Image Principles, Neck, and the Brain provides radiologists and imaging specialists with a valuable, state-of-the-art reference on MRI.

The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, and oncologists. The clinical implications of these achievements have made nuclear medicine indispensable in the management of cancer. This superbly illustrated text on modern nuclear medicine applications in the diagnosis and treatment of cancer describes the state of the art and the current position of nuclear medicine in the light of these recent developments. It is intended as a valuable update also for non-nuclear medicine specialists working in oncology. Nuclear medicine as part of molecular imaging and therapy has changed radically in the last decade. The growing importance and clinical impact of these changes in the near future has impelled the internationallyrenowned editors and contributors to put them on record in "Advances in Nuclear Oncology,"

Magnetic resonance imaging (MRI) is a technique used in biomedical imaging and radiology to visualize internal structures of the body. Because MRI provides excellent contrast between different soft tissues, the technique is especially useful for diagnostic imaging of the brain, muscles, and heart. In the past 20 years, MRI technology has improved significantly with the introduction of systems up to 7 Tesla (7 T) and with the development of numerous post-processing algorithms such as diffusion tensor imaging (DTI), functional MRI (fMRI), and spectroscopic imaging. From these developments, the diagnostic potentialities of MRI have improved impressively with an exceptional spatial resolution and the possibility of analyzing the morphology and function of several kinds of pathology. Given these exciting developments, the Magnetic Resonance Imaging Handbook: Imaging of the Cardiovascular System, Thorax, and Abdomen is a timely addition to the growing body of literature in the field. Offering comprehensive coverage of cutting-edge imaging modalities, this book: Discusses MRI of the heart, blood vessels, lungs, breasts, diaphragm, liver, gallbladder, spleen, pancreas, adrenal glands, and gastrointestinal tract Explains how MRI can be used in vascular, posttraumatic, postsurgical, and computer-aided diagnostic (CAD) applications Highlights each organ's anatomy and pathological processes with high-quality images Examines the protocols and potentialities of advanced MRI scanners such as 7 T systems Includes extensive references at the end of each chapter to enhance further study Thus, the Magnetic Resonance Imaging Handbook: Imaging of the Cardiovascular System, Thorax, and Abdomen provides radiologists and imaging specialists with a valuable, state-of-the-art reference on MRI.

MRI techniques have been recently introduced for non-invasive qualification of regional myocardial mechanics, which is not achievable with other imaging modalities. Covering more than twenty-three years of developments in MRI techniques for accessing heart mechanics, this book provides a plethora of techniques and concepts that assist readers choose the best technique for their purpose. It reviews research studies and clinical trials that implemented MRI techniques for studying heart mechanics.

Based on research and clinical trials, this book details the latest research in magnetic resonance imaging (MRI) tagging technology related to heart mechanics. It covers clinical applications and examines future trends, providing a guide for future uses of MRI technology for studying heart mechanics.

Despite the expected decline in the mid-1970s in the use of computed tomography (CT) following the excitement of magnetic resonance imaging (MRI), CT has confounded its detractors and remains the imaging modality of choice, particularly for the chest and abdomen. Spiral/helical CT with the development of 64-multislice variant has revolutionized diagnostic imaging: image acquistion of large body volumes are obtained in short times during a single-breath hold. Scanning protocols without contrast enhancement are not a challenge; however, with intravenous contrast agents, critical choices are made and bad choices inevitably produce bad scans. This handy guide provides the reader with a simple introduction to the essential ideas involved and a practical guide to the implementation of rational scanning protocols for multislice spiral instruments. Written by Peter Dawson, a well-respected figure in computed tomography and radiology, and a world expert on contrast agents, Scanning Protocols for Multislice Helical Computed Tomography is an essential guide for all those working with CT, as well as those in training.

Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement.

This completely revised and extended second edition: " "Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents.Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations.Is written for all of those involved in the development and application of contrast agents in MRI.Presented in colour, it provides readers with true representation and easy interpretation of the images.

A word from the Authors:

"Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms."

"Reviews of the First Edition: "

..".attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."--Journal of the American Chemical Society..".well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."--NMR in Biomedicine

Kinematic MRI refers to imaging a joint through a range of motion to examine the interactions between the soft tissue and osseous anatomy that comprise the joint. Kinematic MRI techniques were developed because various pathologic conditions are dependent on the specific position of the joint or in response to loading or stress. Importantly, static-view MRI examinations often miss abnormal findings because the joint is not assessed through a range of motion. Accordingly, the functional information obtained using kinematic MRI frequently serves to identify the underlying abnormality or to supplement the information acquired with standard MR imaging techniques.

Kinematic MRI of the Joints is the first textbook on this important, emerging clinical MRI application. For each joint, it presents pertinent functional anatomy, kinesiology, and clinical information; describes the kinematic MRI protocol and technique; explains the normal kinematics; and provides a thorough presentation of the pathokinematics. Multiple case examples illustrate the usefulness of kinematic MRI of the joints for diagnosis or elucidation of pathologic conditions.

Each section of this book is co-authored by an leading musculoskeletal radiologist orthopedic surgeon as well as by an academic-based physical therapist/biomechanist.

This book provides a description of the phenomenon of magnetic resonance and a brief summary of Fourier transformations. It discusses the hardware and electronics of a magnetic resonance imaging scanner, the typical measurements and simulations of magnetic fields, and advanced imaging techniques.

Magnetic resonance imaging (MRI) is a rapidly developing field in basic applied science and clinical practice. Research efforts in this area have already been recognized with five Nobel prizes awarded to seven Nobel laureates in the past 70 years. Based on courses taught at The Johns Hopkins University, Magnetic Resonance Imaging: The Basics provides a solid introduction to this powerful technology. The book begins with a general description of the phenomenon of magnetic resonance and a brief summary of Fourier transformations in two dimensions. It examines the fundamental principles of physics for nuclear magnetic resonance (NMR) signal formation and image construction and provides a detailed explanation of the mathematical formulation of MRI. Numerous image quantitative indices are discussed, including (among others) signal, noise, signal-to-noise, contrast, and resolution. The second part of the book examines the hardware and electronics of an MRI scanner and the typical measurements and simulations of magnetic fields. It introduces NMR spectroscopy and spectral acquisition and imaging techniques employing various pulse sequences. The final section explores the advanced imaging technique of parallel imaging. Structured so that each chapter builds on the knowledge gained in the previous one, the book is enriched by numerous worked examples and problem sets with selected solutions, giving readers a firm grasp of the foundations of MRI technology.

MRI: Essentials for Innovative Technologies describes novel methods to improve magnetic resonance imaging (MRI) beyond its current limitations. It proposes smart encoding methods and acquisition sequences to deal with frequency displacement due to residual static magnetic field inhomogeneity, motion, and undersampling. Requiring few or no hardware modifications, these speculative methods offer building blocks that can be combined and refined to overcome barriers to more advanced MRI applications, such as real-time imaging and open systems.

After a concise review of basic mathematical tools and the physics of MRI, the book describes the severe artifacts produced by conventional MRI techniques. It first tackles magnetic field inhomogeneities, outlining conventional solutions as well as a completely different approach based on time-varying gradients and temporal frequency variation coding (acceleration). The book then proposes two innovative acquisition methods for reducing acquisition time, motion, and undersampling artifacts: adaptive acquisition and compressed sensing. The concluding chapter lays out the author s predictions for the future of MRI.

For some of the proposed solutions, this is the first time the reported results have been published. Where experimental data is preliminary or unavailable, the book presents only numerical solutions. Offering insight into emerging MRI techniques, this book provides readers with specialized knowledge to help them design better acquisition sequences and select appropriate correction methods.

The author s proceeds from the sale of this book will be entirely donated to Bambin Gesu Children s Hospital in Rome.

Fundamentals of MRI: An Interactive Learning Approach explores the physical principles that underpin the technique of magnetic resonance imaging (MRI).

After covering background mathematics, physics, and digital imaging, the book presents fundamental physical principles, including magnetization and rotating reference frame. It describes how relaxation mechanisms help predict tissue contrast and how an MR signal is localized to a selected slice through the body. The text then focuses on frequency and phase encoding. It also explores the spin-echo sequence, its scan parameters, and additional imaging sequences, such as inversion recovery and gradient echo.

The authors enhance the learning experience with practical materials. Along with questions, exercises, and solutions, they include ten interactive programs on the accompanying CD-ROM. These programs not only allow concepts to be clearly demonstrated and further developed, but also provide an opportunity to engage in the learningprocess through guided exercises.

By providing a solid, hands-on foundation in the physics of MRI, this textbook helps students gain confidence with core concepts before they move on to further study or practical training.

The fourth edition of Clinical Nuclear Medicine incorporates the rapid and dramatic changes that have occurred in the field within the last 10 years--particularly the continued growth in clinical applications for PET and other aspects of molecular imaging--so that the book reflects modern practice. With its problem-oriented clinical approach, the book presents relevant topics of current importance to the practicing clinician, rather than providing a comprehensive review of all technical and basic science aspects.
An initial section covers the broad principles and scope of important areas that are considered to have impacted more significantly on current and future clinical practice since the last edition. The second section covers all the clinical systems where nuclear medicine helps current clinical practice, while a third section covers a number of relevant technical topics.