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Molecular and Cellular MR Imaging (Paperback)
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Molecular and Cellular MR Imaging (Paperback)
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The ability of molecular and cellular imaging to track the
survival, migration, and differentiation of cells in vivo as well
as monitor particular gene expression in living subjects is rapidly
moving from the research laboratory into daily clinical settings.
The interdisciplinary nature of the field mandates a constant
dialogue among molecular and cellular biology, chemistry, physics,
image analysis, and drug discovery to develop and translate
promising approaches into reliable scientific applications and
viable clinical diagnostic tools. Bringing together a select panel
of internationally recognized authors, Molecular and Cellular MR
Imaging provides a state-of-the-science overview of the
multidisciplinary nature of the field and illustrates the
application of these various sciences to investigate specific
biological processes in animals and humans. Using a systematic
organization to present diverse information, the text begins with
an introductory chapter that defines cellular and molecular imaging
and explains why magnetic resonance imaging (MRI) is the most
versatile approach for noninvasive, in vivo studies. The first
section examines the physicochemical principles of various contrast
agents including paramagnetic, superparamagnetic, CEST, and
PARACEST agents, as well as smart and sensing agents. The second
section summarizes the wide variety of applications for molecular
imaging of genes and of disease states. Contributions cover cancer,
apoptosis, cardiovascular and neurodegenerative disease, and the
use of pharmacological MRI. The third section is devoted to
cellular imaging under a variety of applications, and the final
section discusses the translational aspects and future directions
of cellular and molecular MR imaging. Molecular and Cellular MR
Imaging highlights the diversity of skills required to translate
advancements in various fields of research into practical
applications that promise to revolutionize in vivo imaging as a
diagnostic
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