This new edition is a comprehensive and updated resource on
antiphospholipid syndrome (APS), which is an autoimmune disorder.
In APS, the body recognizes certain normal components of blood
and/or cell membranes as foreign substances and produces antibodies
(antiphospholipid antibodies) against them. APS is associated with
recurrent clotting events (thrombosis) including premature stroke,
repeated miscarriages, phlebitis, venous thrombosis, and pulmonary
thromboembolism. It is also associated with low platelet or blood
elements that prevent bleeding. Recently, however, even more
disease states have been linked with APS, including premature heart
attack, various cardiac valvular abnormalities, skin lesions,
kidney disease, abnormal involuntary movement/chorea, diseases that
mimic multiple sclerosis, and vascular diseases of the eye that can
lead to visual loss and blindness. The International Congress on
Antiphospholipid Antibodies, held every 3 years, is the venue where
representatives from different disciplines gather to discuss the
recent advances in APS. The conference intends to cover basic
aspects of APS, such as pathogenesis, origins, genetics,
intracellular and molecular events, the role of infections, as well
as traditional and non-traditional clinical manifestations
associated with antiphospholipid antibodies. The 15th Congress took
place in September 2016. A novel aspect of the Congress was that
multiple teams, chaired by Scientific Planning Committee members,
used evidence-based literature reviews and expert discussions to
answer specific pre-defined APS-related questions. These teams
included points of view from experts in rheumatology, hematology,
cardiovascular medicine, obstetrics, neurology, and immunology. The
Scientific Planning Committee members also chaired the congress
sessions and supervised completion of the reports that are the
bases of the chapters of this book. In addition, there are two
chapters included specifically written for APS patients. Much like
the previous volume, dedicated to the 13th International Congress
on Antiphospholipid Antibodies (April 2010), this up-to-date and
comprehensive work gathers invaluable insights from a
multidisciplinary team of world-renowned experts and represents the
authoritative resource on causes, symptoms, diagnosis, and
treatment of APS.
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