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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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G Protein-Coupled Receptor Screening Assays - Methods and Protocols (Hardcover, 2015 ed.)
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G Protein-Coupled Receptor Screening Assays - Methods and Protocols (Hardcover, 2015 ed.)
Series: Methods in Molecular Biology, 1272
Expected to ship within 12 - 17 working days
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This volume explores the considerable efforts that have been
directed towards the development of G Protein-Coupled Receptors
(GPCR) screening assays in order to disclose GPCR acting compounds,
elucidate signaling mechanisms or evaluate compound's efficacy. New
discoveries in the field, along with the widely recognized need for
better and safer pharmaceutical drugs constitute the main
motivation for this book. Readers, both beginners and experienced
researchers, will receive an updated overview of not only the
established, but also the innovative technologies that promise to
advance GPCR drug research. This book is organized into two major
parts: the introductory part discusses the necessary foundations
for the understanding of GPCR action and the rationale behind the
design of the available screening assays; and part two provides
detailed protocols for different screening approaches. Written in
the highly successful Methods in Molecular Biology series format,
the chapters include the kind of detailed description and
implementation advice that is crucial for getting optimal results
in the laboratory. Practical and innovative, G Protein-Coupled
Receptor Screening Assays: Methods and Protocols reaches out to
everyone involved in the discovery of GPCR-active drugs, and
provides a transversal overview of the different levels of GPCR
signaling addressable in the different screening strategies and
presents practical examples of how current assay technologies are
contributing to new paradigms in GPCR drug research.
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