Drs. Franco and Rohan bring together a timely and comprehensive set
of reviews describing the biologic basis of carcinogenesis, issues
related to measurement and interpretation of cancer precursors,
site specific precancerous conditions, and control of cancer
precursors The book has several important strengths, most notably
the wealth of current information on cancer precursors and related
topics provided by an impressive cast of cancer researchers. it
effectively provides specific and compelling reasons for studying
cancer precursors, the most up-to-date and comprehensive collection
of reviews on the topic, and a realistic picture of the
complexities facing research of cancer precursors. American Journal
of Epidemiology "In this book, Drs. Franco and Rohan have succeeded
in preparing a comprehensive, timely, and critical review of the
substantial progress that has been made in our understanding of
cancer precursors. They have enlisted experts in the field who have
contributed authoritative chapters to a wide variety of cancers
with emphasis on the etiology and natural history, including the
role of environmental and heritable factor that provoke normal
cells to undergo malignant transformation. Epidemiologic data are
linked whenever possible to molecular as well as clasical cellular
pathology, providing a fuller understanding of the casual events
and mechanisms that initiate the carcinogenic process." -From the
Foreward by Joseph F. Fraumeni, Jr., M.D., M.S. Director, Division
of Cancer Epidemiology and Genetics National Cancer Institute
National Institutes of Health Rockville, MD This book provides an
overview of the progress made in the last few years on the
epidemiology, detection methods, and preventive stategies for
cancer precursors. Contributors to the 25 chapters are among the
world's most knowledgeable scientists in the areas of molecular
pathology, epidemiology, and control of cancer precursors. Their
reviews of the topic are accessible to a large professional base
that includes basic cancer researchers, clinical oncologists,
pathologists, molecular biologists, epidemiologists, nurses, health
professionals working on policy implications, and graduate students
in cancer-related fields. Divided into five sections, the book
begins with brief overviews of the molecular basis of
carcinogenesis and of the histological aspects of cancer
precursors. Issues related to the measurement, interpretation, and
the study of precursor lesions are addressed in Part II, including
timely chapters on epidemiologic approaches to studying
intermediate endpoints, the impact of measurement error, and
methods of processing biological specimens for molecular
epidemiology studies. The main section of the text is found in Part
III, with chapters on cancer precursors at the most important
anatomical sites at which solid tumors occur, including the lung,
breast, colon, esophagus, and prostate. The site-specific reviews
include discussions of the epidemiology of those lesions, and,
where appropriate, aspects of their detection and prevention. The
final sections of the book feature valuable overviews on screening
and prevention strategies and the role of evidence-based medicine
in judging the value of such strategies for national and
international policy guidelines on cancer control.
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