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The Serotonin Receptors (Hardcover, 1988 ed.)
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Discovery Miles 30 240
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The Serotonin Receptors (Hardcover, 1988 ed.)
Series: The Receptors
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Serotonin (5-HT) was isolated and chemically characterized nearly
four decades ago, and is now generally accepted to function as a
neurotransmitter and neuromodulatory agent. Early research focused
on the measurement of concentrations, synthesis, and metabolism of
5-HT, and only recently has the focus shifted to characterization
of 5-HT receptors. Gaddum and Picarelli first sug gested in 1957
that the effect of 5-HT in the guinea pig ileum is mediated by two
pharmacologically distinguishable receptors; however, the
possibility of dual5-HT receptors was not explored systematically
or successfully until the past decade. It is now clear that more,
perhaps many more, subclasses of 5-HT receptors exist. The purpose
of this book is to provide an up-to-date report on 5-HT receptors.
This is a difficult task considering the astonishing speed at which
research in this field is expanding. As the first of what we can
expect to be a steady stream of monographs focusing on 5-HT
receptors, the book confirms that we are in an exciting time in the
history of 5-HT. For those of us who have been work ing on 5-HT for
many years, our dream of equal progress and recognition with the
more extensively studied catecholamines is finally being realized.
We now have a Serotonin Club that held its first international
scientific meeting in 1987, and several more international meetings
are in the planning stages."
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