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Books > Science & Mathematics > Biology, life sciences > Life sciences: general issues > Evolution
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Recent Advances on Model Hosts (Hardcover, 2012)
Loot Price: R5,708
Discovery Miles 57 080
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Recent Advances on Model Hosts (Hardcover, 2012)
Series: Advances in Experimental Medicine and Biology, 710
Expected to ship within 10 - 15 working days
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Most studies of bacterial or fungal infectious diseases focus
separately on the pathogenic microbe, the host response, or the
characterization of therapeutic compounds. Compartmentalization of
pathogenesis-related research into an analysis of the "pathogen",
the "host," or the "antimicrobial compound" has largely been
dictated by the lack of model systems in which all of these
approaches can be used simultaneously, as well as by the
traditional view that microbiology, immunology, and chemical
biology and pharmacology are separate disciplines. An increasing
number of workers from different fields have turned to insects,
fish, worms and other model hosts as facile, ethically expedient,
relatively simple, and inexpensive hosts to model a variety of
human infectious diseases and to study host responses and innate
immunity. Because many of these hosts are genetically tractable,
they can be used in conjunction with an appropriate pathogen to
facilitate the discovery of novel features of the host innate
immune response. This book provides a series of reports from the
1st International Conference on Model Hosts. This first of its kind
meeting focused on invertebrate, vertebrate and amoeboid systems
used for the study of host-pathogen interactions, virulence and
immunity, as well as on the relevance of these pathogenesis systems
and mammalian models. Importantly, a common, fundamental set of
molecular mechanisms is employed by a significant number of
microbial pathogens against a widely divergent array of metazoan
hosts. Moreover, the evolutionarily conserved immune responses of
these model hosts have contributed important insights to our
understanding of the innate immune response of mammals. This book
provides a series of reports from the 1st International Conference
on Model Hosts. This first of its kind meeting focused on
invertebrate, vertebrate and amoeboid systems used for the study of
host-pathogen interactions, virulence and immunity, as well as on
the relevance of these pathogenesis systems and mammalian models.
Importantly, a common, fundamental set of molecular mechanisms is
employed by a significant number of microbial pathogens against a
widely divergent array of metazoan hosts. Moreover, the
evolutionarily conserved immune responses of these model hosts have
contributed important insights to our understanding of the innate
immune response of mammals.
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