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Pathology of Septic Shock (Paperback, Softcover reprint of the original 1st ed. 1996)
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Pathology of Septic Shock (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Current Topics in Microbiology and Immunology, 216
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Severe sepsis and septic shock are the most serious compli cations
of bacterial infections. Both gram-positive and gram negative
bacteria can trigger these extreme inflammatory re sponses and, by
so doing, cause substantial morbidity and mortality. In the United
States alone, over 400 000 patients suffer from septicaemia each
year, and approximately 100 000 of these patients die despite
optimal intensive care and modern antimicrobial therapy. These
dramatic figures have prompted intensive research to define the
bacterial and host factors involved in the septic response.
Scientists from many disciplines, including chem istry, physics,
biology, medical microbiology, immunology, and pharmacology, have
worked closely with clinicians to achieve rapid and profound
progress. To translate this newly acquired knowledge into clinical
practice, clinical trials have also been performed to evaluate
numerous new therapeutic drugs. The disappointing results from
these trials have underscored a major lesson, namely, that sepsis
constitutes an extremely complex syndrome and that basic and
clinical research must be greatly intensified in order to
illuminate its molecular mechan isms. At this stage, the editors of
the present volume of Current Topics in Microbiology and Immunology
considered it would be rewarding to compile a volume summarizing
our present basic and clinical knowledge on sepsis. Our particular
gratitude extends to those international experts who have followed
our invitation and elaborated on particular areas of the basic and
clinical aspects of this field."
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