Concerned with discovering the chemical pathways of biosynthesis,
this book devotes four chapters to the use of isotopes in
biosynthetic research and the biosynthesis of enzyme cofactors and
vitamin B12 and of reduced polyketides such as erythromycin. The
topics covered demonstrate the revolution that has occurred in
biosynthetic studies with the advent of gene cloning and
overexpression. Yet the book also shows that the more classical
approach to biosynthetic studies must go hand in hand with these
new techniques.
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