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MicroRNA Targeted Cancer Therapy (Hardcover, 2014)
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MicroRNA Targeted Cancer Therapy (Hardcover, 2014)
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Since the discovery of microRNAs (miRNAs) some twenty years ago by
Victor Ambros, David Baulcombe and Gary Ruvkun, these three
scientists worked to uncover the mystery of miRNA, the small
segments of nucleotides that silence genes. While studying the
development of the nematode worm, Ambros and Ruvkun discovered
miRNA in animals, while Baulcombe discovered it in plants. Since
their discovery, it took more than two decade to fully appreciate
the value of miRNA in human health and diseases. Emerging evidence
suggest that the activation of oncogenes and/or the inactivation of
tumor suppressor genes contribute to the development and
progression of tumors. The regulation of genes is by far controlled
by many transcription factors which are often deregulated during
the development and progression of cancer. In addition, emerging
evidence clearly suggests that the deregulation of miRNAs or small
non-coding RNAs could also regulate the expression of genes, and
likewise, miRNA genes are also regulated by transcription factors.
The most attractive feature of miRNAs is that one miRNA can
regulate many target genes (mRNAs), and thus miRNA targeted therapy
is highly promising because multiple genes could be regulated by
targeting a single miRNA, which becomes very important for the
killing of highly heterogeneous populations of cancer cells within
a tumor mass. Therefore, miRNA targeted therapy is an attractive
attribute of miRNA research, which is covered through eighteen
chapters complied in this book "MicroRNA targeted Cancer therapy,"
and it is hoped that the field of miRNA research will be
appreciated through critical reading of these chapters on the
cutting-edge research on miRNAs.
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