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Books > Medicine > Clinical & internal medicine > Cardiovascular medicine
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Apolipoprotein Mimetics in the Management of Human Disease (Paperback, Softcover reprint of the original 1st ed. 2015)
Loot Price: R3,407
Discovery Miles 34 070
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Apolipoprotein Mimetics in the Management of Human Disease (Paperback, Softcover reprint of the original 1st ed. 2015)
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This comprehensive book provides not only the stages in the
development of this unique and specialized field but also updates
on the current state of research and development of apolipoprotein
mimetics as therapeutic modalities for various lipid-mediated
disorders. The book consists of 11 chapters all written by leading
scientists from well-reputed laboratories in the USA. After an
introduction by Dr. Godfrey Getz, Professor of Medicine at the
University of Chicago and the Associate Editor of the Journal Lipid
Research, the book presents a narration of how a theory can lead to
the discovery of treatment modalities to several devastating
diseases such as diabetes, Alzheimer’s disease, arthritis;
asthma; atherosclerosis, chronic rejection of transplanted hearts
and cancer. Present therapies for most of these diseases are not
adequate. Using the models of two long anti-atherogenic and
anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E
with 243 and 299 amino acids, respectively) short mimetic peptides
of 18 to 28 amino acid residues in length, which can be produced
either synthetically or genetically in edible fruits and
vegetables, have been shown to exert profound biological effects in
a large number of animal models of diseases. The book also presents
novel ideas, highly unexpected mechanisms of action in animal
models and even in initial clinical studies in humans, which can
lead to additional improvements in basic and clinical research in
biological science. All the chapters are written by experts in
their respective fields who have contributed immensely to the
literature. This is the first compendium of this growing field
presented in the form of a book.
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