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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Oncology
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Mitochondrial Genetics and Cancer (Hardcover, 2010 ed.)
Loot Price: R6,093
Discovery Miles 60 930
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Mitochondrial Genetics and Cancer (Hardcover, 2010 ed.)
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With very few exceptions, eukaryotic cells possess two
interdependent genomes, chromosomal and extra-chromosomal. Over the
past several decades, cancer - search has focused primarily on
deciphering the intricate alterations in the chro- somal genome,
with until recently, very little attention to its cytoplasmic
counterpart. In spite of the enormous complexity of the nuclear
genome, which we now fully appreciate after completion of the human
genome project, the efforts of cancer researchers are commendable
in terms of the tremendous gains made in unraveling the numerous
genetic changes in cancer. These changes include d- coveries of
tumor suppressor genes, oncogenes, and caretaker genes that are
often mutated in cancer. Recent studies of genomic pro?les are
uncovering even more altered and mutated genes in cancer. Besides
these ?ndings, several therapeutic targets for chemotherapy are
currently made from studies of altered nuclear genetic pathways.
Inspite of all these positive efforts, the war on cancer, declared
in 1971 by Richard Nixon, is far from being worn. Indeed, the
failure of chemotherapy is obvious to clinicians, oncologists, and
their patients alike. Moreover, the global incidence and prevalence
of cancer continue to rise. What are we missing? Which direction
should we be taking? Of course, modern integrated nuclear genomics,
proteomics, and metabolomics should provide important clues to
carcinogenesis, but the contribution of cytoplasmic genetic
alterations to carcinogenesis cannot be neglected.
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