The heart has a very high energy demand but very little energy
reserves. In order to sustain contractile function, the heart has
to continually produce a large amount of ATP.The heart utilizes
free fatty acids mainly and carbohydrates to some extent as
substrates for making energy and any change in this energy supply
can seriously compromise cardiac function.It has emerged that
alterations in cardiac energy metabolism are a major contributor to
the development of a number of different forms of heart disease.It
is also now known that optimizing energy metabolism in the heart is
a viable and important approach to treating various forms of heart
disease.
"Cardiac Energy Metabolism in Health and Disease" describes the
research advances that have been made in understanding what
controls cardiac energy metabolism at molecular, transcriptional
and physiological levels.It also describes how alterations in
energy metabolism contribute to the development of heart
dysfunction and how optimization of energy metabolism can be used
to treat heart disease.The topics covered include a discussion of
the effects of myocardial ischemia, diabetes, obesity, hypertrophy,
heart failure, and genetic disorders of mitochondrial oxidative
metabolism on cardiac energetics.The treatment of heart disease by
optimizing energy metabolism is also discussed, which includes
increasing overall energy production as well as increasing the
efficiency of energy production and switching energy substrate
preference of the heart. This book will be a valuable source of
information to graduate students, postdoctoral fellows, and
investigators in the field of experimental cardiology as well as
biochemists, physiologists, pharmacologists, cardiologists,
cardiovascular surgeons and other health professionals."
General
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